胼胝目灵长类动物 SLC6A4 基因座上与威胁反应相关的多态性的进化。

IF 2.8 2区 生物学 Q2 BIOLOGY
Biology Letters Pub Date : 2024-07-01 Epub Date: 2024-07-17 DOI:10.1098/rsbl.2024.0024
Hanlu Twyman, India Heywood, Marília Barros, Jorge Zeredo, Nicholas I Mundy, Andrea M Santangelo
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引用次数: 0

摘要

编码血清素转运体的 SLC6A4 基因座上游重复区的变异与包括人类和猕猴在内的一些灵长类动物的焦虑相关行为有关,并被认为与猕猴的生态适应性有关。在这项研究中,我们调查了与普通狨猴(Callithrix jacchus)焦虑相关行为有关的SLC6A4多态性的进化。通过对胼胝目灵长类动物(狨猴和犭胥类)八个属 14 个物种的 SLC6A4 重复区的变异进行分析,我们发现重复区的数量(24-43 个)存在很大的种间差异。黑丛耳狨(C. penicillata)的序列多态性与其姊妹种普通狨的序列多态性相似,没有其他物种在这些位点上存在种内变异。我们的结论是,与人类和猕猴类似,普通狨猴 SLC6A4 的功能性多态性也是最近进化而来的,焦虑相关的等位基因也是进化而来的。普通/黑色簇耳狨猴和猕猴具有高度的生态适应性和行为灵活性,我们认为这可能与多态性的维持有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evolution of threat response-related polymorphisms at the SLC6A4 locus in callitrichid primates.

Variation in an upstream repetitive region at the SLC6A4 locus, which encodes the serotonin transporter, is associated with anxiety-related behaviour in a few primate species, including humans and rhesus macaques, and has been suggested to be related to ecological adaptability among macaques. In this study, we investigate evolution of SLC6A4 polymorphisms associated with anxiety-related behaviour in common marmosets (Callithrix jacchus). Assaying variation in the SLC6A4 repeat region across 14 species in eight genera of callitrichid primates (marmosets and tamarins), we find large interspecific variation in the number of repeats present (24-43). The black tufted-ear marmoset (C. penicillata) has sequence polymorphisms similar to those found in the common marmoset, which is its sister species, and no other species has intraspecific variation at these sites. We conclude that, similar to humans and macaques, the functional polymorphism at SLC6A4 in common marmosets has a recent evolutionary origin, and that the anxiety-related allele is evolutionarily derived. Common/black tufted-ear marmosets and rhesus/bonnet macaques share high ecological adaptability and behavioural flexibility that we propose may be related to the maintenance of the polymorphism.

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来源期刊
Biology Letters
Biology Letters 生物-进化生物学
CiteScore
5.50
自引率
3.00%
发文量
164
审稿时长
1.0 months
期刊介绍: Previously a supplement to Proceedings B, and launched as an independent journal in 2005, Biology Letters is a primarily online, peer-reviewed journal that publishes short, high-quality articles, reviews and opinion pieces from across the biological sciences. The scope of Biology Letters is vast - publishing high-quality research in any area of the biological sciences. However, we have particular strengths in the biology, evolution and ecology of whole organisms. We also publish in other areas of biology, such as molecular ecology and evolution, environmental science, and phylogenetics.
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