Hanlu Twyman, India Heywood, Marília Barros, Jorge Zeredo, Nicholas I Mundy, Andrea M Santangelo
{"title":"胼胝目灵长类动物 SLC6A4 基因座上与威胁反应相关的多态性的进化。","authors":"Hanlu Twyman, India Heywood, Marília Barros, Jorge Zeredo, Nicholas I Mundy, Andrea M Santangelo","doi":"10.1098/rsbl.2024.0024","DOIUrl":null,"url":null,"abstract":"<p><p>Variation in an upstream repetitive region at the <i>SLC6A4</i> locus, which encodes the serotonin transporter, is associated with anxiety-related behaviour in a few primate species, including humans and rhesus macaques, and has been suggested to be related to ecological adaptability among macaques. In this study, we investigate evolution of <i>SLC6A4</i> polymorphisms associated with anxiety-related behaviour in common marmosets (<i>Callithrix jacchus</i>). Assaying variation in the <i>SLC6A4</i> repeat region across 14 species in eight genera of callitrichid primates (marmosets and tamarins), we find large interspecific variation in the number of repeats present (24-43). The black tufted-ear marmoset (<i>C. penicillata</i>) has sequence polymorphisms similar to those found in the common marmoset, which is its sister species, and no other species has intraspecific variation at these sites. We conclude that, similar to humans and macaques, the functional polymorphism at <i>SLC6A4</i> in common marmosets has a recent evolutionary origin, and that the anxiety-related allele is evolutionarily derived. Common/black tufted-ear marmosets and rhesus/bonnet macaques share high ecological adaptability and behavioural flexibility that we propose may be related to the maintenance of the polymorphism.</p>","PeriodicalId":9005,"journal":{"name":"Biology Letters","volume":"20 7","pages":"20240024"},"PeriodicalIF":2.8000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251774/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evolution of threat response-related polymorphisms at the <i>SLC6A4</i> locus in callitrichid primates.\",\"authors\":\"Hanlu Twyman, India Heywood, Marília Barros, Jorge Zeredo, Nicholas I Mundy, Andrea M Santangelo\",\"doi\":\"10.1098/rsbl.2024.0024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Variation in an upstream repetitive region at the <i>SLC6A4</i> locus, which encodes the serotonin transporter, is associated with anxiety-related behaviour in a few primate species, including humans and rhesus macaques, and has been suggested to be related to ecological adaptability among macaques. In this study, we investigate evolution of <i>SLC6A4</i> polymorphisms associated with anxiety-related behaviour in common marmosets (<i>Callithrix jacchus</i>). Assaying variation in the <i>SLC6A4</i> repeat region across 14 species in eight genera of callitrichid primates (marmosets and tamarins), we find large interspecific variation in the number of repeats present (24-43). The black tufted-ear marmoset (<i>C. penicillata</i>) has sequence polymorphisms similar to those found in the common marmoset, which is its sister species, and no other species has intraspecific variation at these sites. We conclude that, similar to humans and macaques, the functional polymorphism at <i>SLC6A4</i> in common marmosets has a recent evolutionary origin, and that the anxiety-related allele is evolutionarily derived. Common/black tufted-ear marmosets and rhesus/bonnet macaques share high ecological adaptability and behavioural flexibility that we propose may be related to the maintenance of the polymorphism.</p>\",\"PeriodicalId\":9005,\"journal\":{\"name\":\"Biology Letters\",\"volume\":\"20 7\",\"pages\":\"20240024\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251774/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biology Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1098/rsbl.2024.0024\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology Letters","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1098/rsbl.2024.0024","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Evolution of threat response-related polymorphisms at the SLC6A4 locus in callitrichid primates.
Variation in an upstream repetitive region at the SLC6A4 locus, which encodes the serotonin transporter, is associated with anxiety-related behaviour in a few primate species, including humans and rhesus macaques, and has been suggested to be related to ecological adaptability among macaques. In this study, we investigate evolution of SLC6A4 polymorphisms associated with anxiety-related behaviour in common marmosets (Callithrix jacchus). Assaying variation in the SLC6A4 repeat region across 14 species in eight genera of callitrichid primates (marmosets and tamarins), we find large interspecific variation in the number of repeats present (24-43). The black tufted-ear marmoset (C. penicillata) has sequence polymorphisms similar to those found in the common marmoset, which is its sister species, and no other species has intraspecific variation at these sites. We conclude that, similar to humans and macaques, the functional polymorphism at SLC6A4 in common marmosets has a recent evolutionary origin, and that the anxiety-related allele is evolutionarily derived. Common/black tufted-ear marmosets and rhesus/bonnet macaques share high ecological adaptability and behavioural flexibility that we propose may be related to the maintenance of the polymorphism.
期刊介绍:
Previously a supplement to Proceedings B, and launched as an independent journal in 2005, Biology Letters is a primarily online, peer-reviewed journal that publishes short, high-quality articles, reviews and opinion pieces from across the biological sciences. The scope of Biology Letters is vast - publishing high-quality research in any area of the biological sciences. However, we have particular strengths in the biology, evolution and ecology of whole organisms. We also publish in other areas of biology, such as molecular ecology and evolution, environmental science, and phylogenetics.