肠道微生物群在不同的系统性红斑狼疮小鼠模型中的作用。

IF 3.3 4区医学 Q3 IMMUNOLOGY

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI:10.1080/08916934.2024.2378876

Ran Lu, Xin M Luo

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引用次数: 0

摘要

系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特点是免疫系统功能紊乱，可导致严重的健康问题和死亡。最近的研究强调了肠道微生物群的改变在调节系统性红斑狼疮的炎症和疾病严重程度中的作用。本综述特别总结了各种狼疮小鼠模型中肠道微生物群组成的差异。通过关注这些差异，我们旨在阐明在临床前环境中肠道微生物群失调与系统性红斑狼疮的发生和发展之间错综复杂的关系。

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The role of gut microbiota in different murine models of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune system dysfunction that can lead to serious health issues and mortality. Recent investigations highlight the role of gut microbiota alterations in modulating inflammation and disease severity in SLE. This review specifically summaries the variations in gut microbiota composition across various murine models of lupus. By focusing on these differences, we aim to elucidate the intricate relationship between gut microbiota dysbiosis and the development and progression of SLE in preclinical settings.

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来源期刊

Autoimmunity 医学-免疫学

CiteScore

5.70

自引率

8.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.