含苯并噻唑-恶唑-吡嗪的查尔酮官能团作为抗癌剂的设计、合成和抗癌评估

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2024-06-17 DOI:10.1016/j.cdc.2024.101153

P. Venkata Ramana Reddy , Dasari Sravani , Dittakavi Ramachandran , Ponnuri Bharath

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引用次数: 0

摘要

本研究设计、合成了一个新的含苯并噻唑-噁唑-吡嗪（10a-j）衍生物的查尔酮官能团，并采用 MTT 法筛选了它们对 MCF-7（乳腺癌）、A549（肺癌）、Colo-205（结肠癌）和amp; A2780（卵巢癌）等四种人类癌细胞系的抗癌活性。结果与作为阳性对照的依托泊苷进行了比较。与依托泊苷相比，大多数受试化合物显示出良好至中等程度的活性。其中，化合物 10j 对 MCF-7、A549、Colo-205 和 A2780 细胞株具有强效抗癌活性，IC50 值分别为 0.01 ± 0.0073 µM、0.03 ± 0.0087 µM、0.06 ± 0.0066 µM 和 0.13 ± 0.055 µM

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Design, synthesis and anticancer evaluation of chalcone functionality bearing benzothiazol-oxazole-pyrazine as anticancer agents

A new library of chalcone functionality bearing benzothiazol-oxazole-pyrazine (10a-j) derivatives were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay. The results were compared with the etoposide used as a positive control. Most of the tested compounds displayed good to moderate activity compared to etoposide. Among them, compound 10j showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines with IC₅₀ values of 0.01 ± 0.0073 µM, 0.03 ± 0.0087 µM, 0.06 ± 0.0066 µM, and 0.13 ± 0.055 µM respectively

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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