针对多发性骨髓瘤患者的多学科小组生存干预:可行性研究。

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Nora Eilert, Norma-Jean Murphy, Hannah Cummins, Emma Houlihan, Janusz Krawczyk
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引用次数: 0

摘要

背景:虽然多发性骨髓瘤仍然是一种无法治愈的癌症,但对它的认识和管理方面的进步已使存活率显著提高。尽管有越来越多的证据表明,多发性骨髓瘤幸存者的多种支持需求尚未得到满足,但针对多发性骨髓瘤患者的幸存者干预措施仍然很少。本研究旨在评估一种基于多学科小组的新型多发性骨髓瘤生存干预措施的可行性和初步有效性:方法:在一项常规癌症支持服务中开展了一项混合方法、重复测量可行性研究。七名年龄在 18 岁以上、确诊为多发性骨髓瘤并经血液肿瘤科医生临床评估适合接受干预的参与者参加了每周六次的在线体育锻炼和自我管理小组课程,并在基线、干预后和随访期间完成了定性、体能和自我报告测量:结果:干预被认为总体可行,接受率相对较高,参与者认为干预基本可接受且适当,并提出了改进干预可行性的建议。有关干预措施初步效果的调查结果不一。虽然定性分析强调了干预措施的益处(如同伴支持、连通性、改善幸福感),并观察到大多数身体结果都有较大的效应大小,但自我报告的结果(如生活质量、疲劳)却没有改善:本研究是首次针对多发性骨髓瘤患者的新型生存干预进行的调查,强调了同伴支持的重要性,未来的临床试验将在此基础上建立常规护理干预的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A multidisciplinary group-based survivorship intervention for those living with multiple myeloma: a feasibility study.

Background: While multiple myeloma continues to be an incurable cancer, advances in its understanding and management have led to significantly improved survival rates. Survivorship interventions for those living with multiple myeloma remain scarce, despite mounting evidence for multiple unmet support needs among multiple myeloma survivors. The current study aimed to evaluate the feasibility and preliminary effectiveness of a novel multidisciplinary group-based multiple myeloma survivorship intervention.

Methods: A mixed-method, repeated measures feasibility study was conducted within a routine cancer support service. Seven participants, aged over 18, who had a multiple myeloma diagnosis and were clinically assessed as suitable for the intervention by their haemato-oncologist, attended online for six weekly group sessions of physical exercise and self-management input, completing qualitative, physical and self-report measures at baseline, post-intervention and follow-up.

Results: The intervention was deemed overall feasible, with relatively high uptake, participants describing it as largely acceptable and appropriate and providing recommendations for feasibility-enhancing intervention refinements. Findings regarding the preliminary effectiveness of the intervention were mixed. While qualitative analyses stressed the benefits of the intervention (e.g. peer support, connectedness, improved well-being) and large effect sizes were observed for most physical outcomes, no improvements in self-reported outcomes (i.e. quality of life, fatigue) were reported.

Conclusions: This study represents the first investigation of a promising novel survivorship intervention for those living with multiple myeloma, highlighting the importance of peer support in particular, on which future clinical trials, aiming to establish the intervention's effectiveness for routine care, will be able to build.

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来源期刊
Pilot and Feasibility Studies
Pilot and Feasibility Studies Medicine-Medicine (miscellaneous)
CiteScore
2.70
自引率
5.90%
发文量
241
审稿时长
9 weeks
期刊介绍: Pilot and Feasibility Studies encompasses all aspects of the design, conduct and reporting of pilot and feasibility studies in biomedicine. The journal publishes research articles that are intended to directly influence future clinical trials or large scale observational studies, as well as protocols, commentaries and methodology articles. The journal also ensures that the results of all well-conducted, peer-reviewed, pilot and feasibility studies are published, regardless of outcome or significance of findings. Pilot and feasibility studies are increasingly conducted prior to a full randomized controlled trial. However, these studies often lack clear objectives, many remain unpublished, and there is confusion over the meanings of the words “pilot” and “feasibility”. Pilot and Feasibility Studies provides a forum for discussion around this key aspect of the scientific process, and seeks to ensure that these studies are published, so as to complete the publication thread for clinical research.
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