甲氧氟醚镇痛用于门诊宫腔镜检查:双盲随机对照试验。

IF 1.4 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Emily K Twidale, Sofie Neutens, Lyn Hynt, Narena Dudley, Catherine Streeton
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引用次数: 0

摘要

背景:尽管具有临床和经济效益,但门诊宫腔镜检查(OPH)期间的疼痛仍是使用的障碍。目的:研究甲氧氟醚镇痛在 OPH 期间的有效性和安全性:进行了一项单中心、随机、双盲、安慰剂对照实验;90名患者被随机分配(1:1)。被分配到治疗组(病例)的患者通过吸入器吸入 3 毫升甲氧氟醚。对照组接受安慰剂治疗。主要结果是在诊断性宫腔镜检查时,通过视觉模拟量表(VAS)评分与基线相比的变化,得出疼痛的平均差异。次要结果包括:任何后续手术过程中 VAS 评分的平均差异;术后 15 分钟 VAS 评分的平均差异;参与者和临床医生报告的不良反应和事件;参与者报告的手术可接受性、辅助一氧化二氮(N2O2)的使用情况以及 "痛苦 "的综合指数:在诊断性宫腔镜检查过程中,病例与对照组相比,得分较低,平均差异为 11.5 mm/100(95% 置信区间 (CI):0.08-22.95),P = 0.05。在随后的手术过程中,与对照组相比,病例的疼痛评分较低,平均差异为 15 mm/100(95% 置信区间 2.71-28.22),P = 0.02。在术后15分钟疼痛、参与者和临床医生报告的不良反应和事件、手术可接受性和 "痛苦 "综合评分方面没有明显差异:结论:与安慰剂相比,甲氧氟烷能明显减轻 OPH 诊断和手术过程中的疼痛。此外,甲氧氟烷的耐受性良好,没有不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Methoxyflurane analgesia for outpatient hysteroscopy: A double-blind, randomised, controlled trial.

Background: Despite clinical and economic benefits, pain during outpatient hysteroscopy (OPH) remains a barrier to use. There is a lack of evidence to support routine use of one analgesic over another versus no analgesic.

Aims: To study the efficacy and safety of methoxyflurane analgesia during OPH.

Materials and methods: A single-centre, randomised, double-blind, placebo-controlled experiment was performed; 90 patients were randomly assigned (1:1). Participants allocated to the treatment group (cases) received 3 mL of methoxyflurane through an inhaler. The control group received a placebo. The primary outcome was a mean difference in pain, via a change in Visual Analog Scale (VAS) score from baseline at diagnostic hysteroscopy. Secondary outcomes were a mean difference in VAS score with any subsequent operative procedures; a mean difference in VAS score at 15 min post-procedure; participant and clinician-reported adverse effects and events; and participant-reported procedure acceptability, adjuvant nitrous oxide (N2O2) use and a composite of 'distress'.

Results: During diagnostic hysteroscopy, there was a mean difference of 11.5 mm/100 (95% confidence interval (CI) 0.08-22.95), P = 0.05, with the lower score in the cases, compared with controls. During subsequent operative procedures, there was a mean difference of 15 mm/100 (95% CI 2.71-28.22), P = 0.02, with the lower pain score in the cases, compared with controls. There was no significant difference in pain 15 min post-procedure, participant- and clinician- reported adverse effects and events, procedure acceptability and the 'distress' composite.

Conclusions: Methoxyflurane significantly reduced pain during OPH compared with placebo, for diagnostic as well as operative procedures. Furthermore, methoxyflurane was well tolerated, with no adverse events.

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来源期刊
CiteScore
3.40
自引率
11.80%
发文量
165
审稿时长
4-8 weeks
期刊介绍: The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG) is an editorially independent publication owned by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) and the RANZCOG Research foundation. ANZJOG aims to provide a medium for the publication of original contributions to clinical practice and/or research in all fields of obstetrics and gynaecology and related disciplines. Articles are peer reviewed by clinicians or researchers expert in the field of the submitted work. From time to time the journal will also publish printed abstracts from the RANZCOG Annual Scientific Meeting and meetings of relevant special interest groups, where the accepted abstracts have undergone the journals peer review acceptance process.
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