心房颤动和高龄可预测心力衰竭患者的血清脑源性神经营养因子水平

IF 1.7 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Nursing Pub Date : 2024-07-10 DOI:10.1097/JCN.0000000000001110

Susan J Pressler, Miyeon Jung, Susan G Dorsey, Bruno Giordani, Marita G Titler, Kelly L Wierenga, David G Clark, Dean G Smith, Asa B Smith, Irmina Gradus-Pizlo, Milton L Pressler

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引用次数: 0

摘要

背景：心衰患者血清脑源性神经营养因子（BDNF）水平的预测因素尚未确定：心力衰竭（HF）患者血清脑源性神经营养因子（BDNF）水平的预测因素尚未确定：主要目的是评估心房颤动史、年龄、性别和左心室射血分数对心力衰竭患者基线、10周、基线后4个月和8个月血清BDNF水平的预测作用：本研究对 241 名高血压患者进行了回顾性队列分析。数据来自患者的健康记录（心房颤动病史、左心室射血分数）、自我报告（年龄、性别）和血清BDNF。结果显示：133 名患者（42.7%）患有心房颤动：103 名患者（42.7%）有心房颤动病史。在基线（β = -0.16，P = .016）、4 个月（β = -0.21，P = .005）和 8 个月（β = -0.19，P = .015）时，心房颤动史对血清 BDNF 水平有显著的预测作用。在10周（β = -0.17，P = .017）和4个月（β = -0.15，P = .046）时，年龄较大是一个重要的预测因素：需要进行前瞻性研究来验证这些结果。临床医生需要对心房颤动的高血压患者进行评估，并将心房颤动的治疗纳入管理计划中。

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Atrial Fibrillation and Older Age Predict Serum Brain-Derived Neurotrophic Factor Levels Among Patients With Heart Failure.

Background: Predictors have not been determined of serum brain-derived neurotrophic factor (BDNF) levels among patients with heart failure (HF).

Objective: The primary purpose was to evaluate history of atrial fibrillation, age, gender, and left ventricular ejection fraction as predictors of serum BDNF levels at baseline, 10 weeks, and 4 and 8 months after baseline among patients with HF.

Methods: This study was a retrospective cohort analyses of 241 patients with HF. Data were retrieved from the patients' health records (coded history of atrial fibrillation, left ventricular ejection fraction), self-report (age, gender), and serum BDNF. Linear multiple regression analyses were conducted.

Results: One hundred three patients (42.7%) had a history of atrial fibrillation. History of atrial fibrillation was a significant predictor of serum BDNF levels at baseline (β = -0.16, P = .016), 4 months (β = -0.21, P = .005), and 8 months (β = -0.19, P = .015). Older age was a significant predictor at 10 weeks (β = -0.17, P = .017) and 4 months (β = -0.15, P = .046).

Conclusions: Prospective studies are needed to validate these results. Clinicians need to assess patients with HF for atrial fibrillation and include treatment of it in management plans.

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来源期刊

Journal of Cardiovascular Nursing 医学-护理

CiteScore

3.30

自引率

10.00%

发文量

154

审稿时长

>12 weeks

期刊介绍： Official journal of the Preventive Cardiovascular Nurses Association, Journal of Cardiovascular Nursing is one of the leading journals for advanced practice nurses in cardiovascular care, providing thorough coverage of timely topics and information that is extremely practical for daily, on-the-job use. Each issue addresses the physiologic, psychologic, and social needs of cardiovascular patients and their families in a variety of environments. Regular columns include By the Bedside, Progress in Prevention, Pharmacology, Dysrhythmias, and Outcomes Research.