闭塞后反应性充血过程中微循环血流运动的稳健分析

IF 2.9 4区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Martin Hultman , Freya Richter , Marcus Larsson , Tomas Strömberg , Fredrik Iredahl , Ingemar Fredriksson
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引用次数: 0

摘要

背景:微循环血流运动分析是一种提取血管调节功能信息的方法。以前,当应用于闭塞后反应性充血时的测量时,它显示出了良好的前景。再灌注峰值和随后的单调下降会带来错误的低频,不应被解释为节律性血管运动效应。目的:开发并验证一种对闭塞后反应性高血流信号进行血流运动分析的稳健方法:方法:闭塞诱导的再灌注反应包含典型的快速上升,随后单调下降至基线。我们提出了一个数学模型来对信号的这一瞬态部分进行去趋势化,以便进一步进行血流运动分析。该模型在对健康志愿者进行的 96 次测量中得到了验证:结果:应用所提出的模型可以校正血流运动信号,而不会增加任何新的错误血流运动成分:结论:今后的研究在分析闭塞后反应性充血时的血流运动时,应使用建议的方法或同等方法,以确保结果的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Robust analysis of microcirculatory flowmotion during post-occlusive reactive hyperemia

Background

Flowmotion analysis of the microcirculatory blood flow is a method to extract information about the vessel regulatory function. It has previously shown promise when applied to measurements during a post-occlusive reactive hyperemia. However, the reperfusion peak and the following monotonic decline introduces false low frequencies that should not be interpreted as rhythmic vasomotion effect.

Aim

To develop and validate a robust method for flowmotion analysis of post-occlusive reactive hyperemia signals.

Method

The occlusion-induced reperfusion response contains a typical rapid increase followed by a monotonic decline to baseline. A mathematical model is proposed to detrend this transient part of the signal to enable further flowmotion analysis. The model is validated in 96 measurements on healthy volunteers.

Results

Applying the proposed model corrects the flowmotion signal without adding any substantial new false flowmotion components.

Conclusion

Future studies should use the proposed method or equivalent when analyzing flowmotion during post-occlusive reactive hyperemia to ensure valid results.

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来源期刊
Microvascular research
Microvascular research 医学-外周血管病
CiteScore
6.00
自引率
3.20%
发文量
158
审稿时长
43 days
期刊介绍: Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.
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