抗黑色素瘤分化抗原 5 阳性皮肌炎:最新进展。

IF 5.2 2区 医学 Q1 RHEUMATOLOGY
Xin Lu, Qinglin Peng, Guochun Wang
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引用次数: 0

摘要

综述的目的:抗黑色素瘤分化抗原5-皮肌炎(MDA5-DM)是一种复杂而严重的系统性自身免疫性疾病,主要影响皮肤和肺部。在这篇综述中,我们旨在为该病的临床特征、发病机制和实际管理方法提供新的见解:虽然肺部病变在大多数 MDA5-DM 患者中都很突出,但现在已被公认为是一种异质性疾病。外周血淋巴细胞计数可作为一种简单可靠的实验室参数,将 MDA5-DM 患者分为轻度、中度和重度三个亚组。最近的研究表明,病毒感染、遗传因素、针对 MDA5 的自身免疫、多种免疫细胞和干扰素是导致 MDA5-DM 发病的重要因素。除了使用糖皮质激素和免疫抑制剂进行传统治疗外,还探索了许多新方法,包括新型生物制剂和靶向药物。此外,感染是 MDA5-DM 常见的并发症,预防或治疗感染与治疗原发病同等重要。尽管已探索出许多新的治疗方法,但仍需进一步研究以确认其疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimelanoma differentiation antigen 5-positive dermatomyositis: an update.

Purpose of review: Antimelanoma differentiation antigen 5-dermatomyositis (MDA5-DM) is a complex and serious systemic autoimmune disease that primarily affects the skin and lungs. In this review, we aimed to provide new insights into the clinical features, pathogenesis, and practical management approach for this disease.

Recent findings: Although lung lesions are prominent in most patients with MDA5-DM, they are now recognized as heterogeneous diseases. Peripheral blood lymphocyte count can serve as a simple and reliable laboratory parameter for categorizing MDA5-DM into three subgroups: mild, medium, and severe. Recent studies have implicated viral infection, genetic factors, autoimmunity against MDA5, multiple immune cells, and interferons as significant contributors to MDA5-DM pathogenesis. In addition to traditional treatments with glucocorticoids and immunosuppressants, many new approaches, including new biologics and targeted agents, have been explored. Additionally, infection is a common complication of MDA5-DM, and prophylaxis or treatment of the infection is as important as treating the primary disease.

Summary: Knowledge of clinical characteristics and pathogenesis of MDA5-DM has grown in recent years. Although many new therapeutic approaches have been explored, further studies are required to confirm their efficacy.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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