对乙酰氨基酚与二油酰磷脂酰胆碱膜之间受 pH 值影响的相互作用

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-07-12 DOI:10.1093/chemle/upae133

Kodai Ishikawa, Hideki Nabika

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引用次数: 0

摘要

过量服用对乙酰氨基酚可能会导致急性肝功能衰竭。了解对乙酰氨基酚吸附和融入细胞膜的过程对于阐明对乙酰氨基酚的作用机制和毒性至关重要。我们利用表面压力-面积等温线研究了对乙酰氨基酚与模型细胞膜（二油酰磷脂酰胆碱）之间的相互作用。在碱性条件下，对乙酰氨基酚与二油酰磷脂酰胆碱膜结合，增加了二油酰磷脂酰胆碱的分子面积。对乙酰氨基酚吸收的原因是氢氧根离子在脂膜上的吸附以及对乙酰氨基酚与脂质分子在碱性条件下的静电作用。

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pH-dependent interaction between acetaminophen and dioleoylphosphatidylcholine membranes

Acetaminophen may cause acute liver failure due to overdose. Understanding the processes of adsorption and incorporation of acetaminophen into cell membranes is crucial for elucidating the mechanisms of action and toxicity of acetaminophen. We investigated the interaction between acetaminophen and a model cell membrane (dioleoylphosphatidylcholine) using surface pressure–area isotherms. Acetaminophen was incorporated into the dioleoylphosphatidylcholine membrane under basic conditions, increasing the dioleoylphosphatidylcholine molecular area. The acetaminophen uptake was explained by the adsorption of hydroxide ions onto the lipid membrane and electrostatic interaction between acetaminophen and lipid molecules under basic conditions.

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry