膀胱内给药策略:从膀胱生理屏障和潜在的运输机制入手

IF 14.7 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Zheng-an Li , Kai-chao Wen , Ji-heng Liu , Chuan Zhang , Feng Zhang , Feng-qian Li
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引用次数: 0

摘要

膀胱内给药作为一种非侵入性的局部给药途径,对膀胱疾病,尤其是膀胱癌具有重要的临床意义。尽管膀胱内给药具有许多优点,如增强病灶药物暴露和避免全身药物不良反应,但膀胱的生理屏障对给药的有效性提出了极大挑战。在这篇综述中,首先讨论了 IDD 所遇到的途径和障碍,并关注了药物潜在的内部/粘膜滞留和吸收-转运机制。在此基础上,进一步强调了如何避免、克服和利用 "三障",并主要从构建药物储库、增强渗透性和靶向性等方面阐述了目前膀胱内给药系统(IDDS)的设计和制造策略,希望能为新型膀胱内给药系统的研究及其对膀胱疾病的治疗提供系统的认识和启发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Strategies for intravesical drug delivery: From bladder physiological barriers and potential transport mechanisms

Strategies for intravesical drug delivery: From bladder physiological barriers and potential transport mechanisms

Strategies for intravesical drug delivery: From bladder physiological barriers and potential transport mechanisms
Intravesical drug delivery (IDD), as a noninvasive, local pathway of administration, has great clinical significance for bladder diseases, especially bladder cancer. Despite the many advantages of IDD such as enhanced focal drug exposure and avoidance of systemic adverse drug reactions, the effectiveness of drug delivery is greatly challenged by the physiological barriers of the bladder. In this review, the routes and barriers encountered in IDD are first discussed, and attention is paid to the potential internal/mucosal retention and absorption-transport mechanisms of drugs. On this basis, the avoidance, overcoming and utilization of the "three barriers" is further emphasized, and current design and fabrication strategies for intravesical drug delivery systems (IDDSs) are described mainly from the perspectives of constructing drug reservoirs, enhancing permeability and targeting, with the hope of providing systematic understanding and inspirations for the research of novel IDDSs and their treatment of bladder diseases.
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来源期刊
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
22.40
自引率
5.50%
发文量
1051
审稿时长
19 weeks
期刊介绍: The Journal of the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association oversees the peer review process for Acta Pharmaceutica Sinica. B (APSB). Published monthly in English, APSB is dedicated to disseminating significant original research articles, rapid communications, and high-quality reviews that highlight recent advances across various pharmaceutical sciences domains. These encompass pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis, and pharmacokinetics. A part of the Acta Pharmaceutica Sinica series, established in 1953 and indexed in prominent databases like Chemical Abstracts, Index Medicus, SciFinder Scholar, Biological Abstracts, International Pharmaceutical Abstracts, Cambridge Scientific Abstracts, and Current Bibliography on Science and Technology, APSB is sponsored by the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association. Its production and hosting are facilitated by Elsevier B.V. This collaborative effort ensures APSB's commitment to delivering valuable contributions to the pharmaceutical sciences community.
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