蜂胶/藏红花提取物/姜黄素负载型 ZIF8 纳米粒子的抗炎活性体外研究及其在治疗骨关节炎中的潜在应用

IF 1.3 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Science-Poland Pub Date : 2024-07-11 DOI:10.2478/msp-2024-0016

Hongtao Zhang, Kui Xu, Zhen Zhao, Chuan Dong, Yunfei Zhang

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引用次数: 0

摘要

背景骨关节炎（OA）是全球面临的一项重大医疗挑战，需要开发有效的治疗干预措施。开发治疗骨关节炎的新型给药系统至关重要。目的本研究探讨了蜂胶、藏红花提取物和姜黄素负载的沸石咪唑酸框架-8（ZIF8）纳米粒子作为治疗 OA 的一种方法的潜力。这些天然化合物具有抗炎和保护软骨的特性，因此有望成为治疗 OA 的候选药物。方法通过全面的体外研究，包括扫描电子显微镜（SEM）、MTT 试验、抗炎试验、细胞迁移试验、傅立叶变换红外光谱（FTIR）和释放试验，我们评估了蜂胶、藏红花提取物和姜黄素负载的 ZIF8 纳米载体的理化和生物学特性。结果我们的研究结果表明，这些纳米载体能有效封装生物活性化合物，表现出持续释放特性，并具有显著的抗炎特性。值得注意的是，与其他制剂相比，蜂胶负载的 ZIF8 纳米载体具有更强的抗炎活性。将蜂胶、藏红花提取物和姜黄素封装在 ZIF8 纳米颗粒中，有望提高它们的疗效，并确保在治疗 OA 时有针对性地输送到受影响的关节。结论本研究强调了基于纳米技术的给药系统在利用天然化合物治疗 OA 方面的潜力。

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In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis

Background Osteoarthritis (OA) poses a significant healthcare challenge globally, necessitating the development of effective therapeutic interventions. It is crucial to develop novel drug delivery systems for OA treatment. Aims This study explores the potential of propolis, saffron extract, and curcumin-loaded zeolitic imidazolate framework-8 (ZIF8) nanoparticles as a treatment modality for OA. The anti-inflammatory and chondroprotective properties of these natural compounds make them promising candidates for OA management. Methods Through comprehensive in vitro investigations, including scanning electron microscopy (SEM), MTT assays, antiinflammatory assays, cell migration assays, Fourier transform infrared (FTIR) spectroscopy, and release assays, we evaluated the physicochemical and biological characteristics of propolis, saffron extract, and curcumin-loaded ZIF8 nanocarriers. Results Our findings demonstrate that these nanocarriers effectively encapsulated the bioactive compounds, exhibited sustained release profiles, and displayed significant anti-inflammatory properties. Notably, propolis-loaded ZIF8 nanocarriers exhibited superior anti-inflammatory activity compared to other formulations. The encapsulation of propolis, saffron extract, and curcumin within ZIF8 nanoparticles holds promise for enhancing their therapeutic efficacy and ensuring targeted delivery to affected joints in OA treatment. Conclusion This study highlights the potential of nanotechnology-based delivery systems in harnessing the therapeutic benefits of natural compounds for OA management.

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来源期刊

Materials Science-Poland MATERIALS SCIENCE, MULTIDISCIPLINARY-

自引率

18.20%

发文量

期刊介绍： Material Sciences-Poland is an interdisciplinary journal devoted to experimental research into results on the relationships between structure, processing, properties, technology, and uses of materials. Original research articles and review can be only submitted.