钌(ii)和铱(iii)的新型半三明治配合物。研究它们对 Hela 的毒性

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Pure and Applied Chemistry Pub Date : 2024-07-12 DOI:10.1515/pac-2024-0224

Alfonso Canales-Martínez, Rosa M. Pérez-Pastor, Gabriel García

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引用次数: 0

摘要

在这项工作中，我们描述了起始材料 [Cp*IrCl2]2 和四种新的钌(II)和铱(III)配合物半夹心的合成和表征：[Cp*IrCl2(2-氨基吡啶)] (I)、[Cp*IrCl2(4-氨基吡啶)] (II)、[Cp*IrCl2(腺嘌呤)] (III) 和 [(对伞花烃)RuCl2(腺嘌呤)] (IV)。新化合物的表征方法包括：C、H 和 N 元素分析；红外和 1H NMR 光谱及 1H-1H COSY、ESI/TOF 质谱分析和热重分析。对这些化合物对 Hela 细胞系的细胞毒性进行了研究，结果表明活性较低。

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New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela

In this work, we describe the synthesis and characterisation of the starting materials [Cp*IrCl2]2 and four new ruthenium(II) and iridium(III) complexes half sandwich, contain the fragments [(p-cymene)Ru]2+ and [Cp*Ir]2+; (Cp* = CpMe4Et) of stoichiometry: [Cp*IrCl2(2-aminopyridine)] (I), [Cp*IrCl2(4-aminopyridine)] (II), [Cp*IrCl2(adenine)] (III) and [(p-cymene)RuCl2(adenine)] (IV). The new compounds have been characterised by C, H, and N elemental analysis; infrared and 1H NMR spectroscopy with 1H–1H COSY, ESI/TOF mass spectrometry and thermogravimetry. A study of the cytotoxicity of these compounds against the Hela cell line was carried out, with results indicating a low activity.

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来源期刊

Pure and Applied Chemistry 化学-化学综合

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Pure and Applied Chemistry is the official monthly Journal of IUPAC, with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union. The policy is to publish highly topical and credible works at the forefront of all aspects of pure and applied chemistry, and the attendant goal is to promote widespread acceptance of the Journal as an authoritative and indispensable holding in academic and institutional libraries.