负载金属有机框架的外泌体水凝胶通过抑制氧化应激改善皮肤衰老

IF 0.7 4区工程技术 Q4 CHEMISTRY, APPLIED

Polish Journal of Chemical Technology Pub Date : 2024-07-12 DOI:10.2478/pjct-2024-0017

Li-Jie Li, Qing-Ling Han, Wen-Jie Feng, Zhan-Peng Wang, Hong-Hua Li

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引用次数: 0

摘要

Ba(NO3)2 与 1,3,5-苯三羧酸的溶热反应产生了一种新的配位聚合物 [Ba6(BTC)4(H2O)9]}n（1 H3BTC = 苯三羧酸）。傅立叶变换红外光谱（FT-IR）、元素分析（EA）、单晶 X 射线衍射（SCXRD）和热重分析（TGA）对复合物 1 进行了可靠的表征。1 的框架具有很高的热稳定性，并能在室温下发出强烈的荧光。透明质酸（HA）和羧甲基壳聚糖（CMCS）具有良好的生物相容性，基于化学合成方法，制备了HA/CMCS水凝胶。以外泌体为药物模型，我们进一步合成了新型外泌体负载金属凝胶颗粒，并评估了其对人真皮成纤维细胞氧化应激的影响。

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Exosome-hydrogels loaded with metal-organic framework improve skin aging by inhibiting oxidative stress

Solvothermal reactions of Ba(NO3)2 with 1,3,5-benzenetricarboxylic acid gave rise to a new coordination polymer of [Ba6(BTC)4(H2O)9]}n (1 H3BTC = benzenetricarboxylic acid). The complex 1 was characterized soundly by Fourier transform infrared (FT-IR) spectroscopy, elemental analysis (EA), single-crystal X-ray diffraction (SCXRD), and thermogravimetric analysis (TGA). The framework of 1 has high thermal stability and shows intense luminescence at room temperature. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) have good biocompatibility, based on the chemical synthesis method, the HA/CMCS hydrogel was prepared. With exosomes as drug models, we further synthesized novel exosome-loaded metal gel particles and evaluated their effects on oxidative stress in human dermal fibroblasts.

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来源期刊

Polish Journal of Chemical Technology CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL

CiteScore

1.70

自引率

10.00%

发文量

审稿时长

4.5 months

期刊介绍： Polish Journal of Chemical Technology is a peer-reviewed, international journal devoted to fundamental and applied chemistry, as well as chemical engineering and biotechnology research. It has a very broad scope but favors interdisciplinary research that bring chemical technology together with other disciplines. All authors receive very fast and comprehensive peer-review. Additionally, every published article is promoted to researchers working in the same field.