{"title":"亚麻籽补充剂会影响载脂蛋白吗？","authors":"Sasan Pourbagher Benam , Seyedsaber Mirabdali , Negar Ebrahimi , Maziar Daneshvar , Shima Vahedi , Fateme Abbasifard , Mahsa Rounagh","doi":"10.1016/j.prostaglandins.2024.106872","DOIUrl":null,"url":null,"abstract":"<div><p>Several studies indicated the ameliorating effects of flaxseed supplementation on apolipoproteins, although others have conflicting results. Therefore, the present research was conducted in order to accurately and definitively understand the effect of flaxseed on apolipoproteins in adults. All articles published up to Juan 2024 were systematically searched through PubMed, Scopus, Embase, and Web of Science to collect all randomized clinical trials (RCTs). A random effects model was used to measure the combined effect sizes. Also, standardized mean difference (SMD) and 95 % confidence interval (CI) were used to report the combined effect size. Our results showed that flaxseed supplementation significantly reduced apo-BI (SMD: −0.57; 95 % CI: −0.95, −0.19, p = 0.003; <em>I</em><sup>2</sup> = 83.2 %, heterogeneity p < 0.001) and lipo(a) decreased (SMD: −0.34; 95 % CI: −0.59, −0.09, p=0.007; <em>I</em><sup>2</sup>=30.3 %, heterogeneity p=0.197). However, flaxseed did not change apo-AI levels (SMD: −0.37; 95 % CI: −0.87, 0.13, p = 0.146; <em>I</em><sup>2</sup> = 89.2 %, p-heterogeneity < 0.001). This meta-analysis has shown that flaxseed supplementation may have beneficial effects on apolipoproteins. Future high-quality, long-term clinical trials are needed to confirm our results.</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"174 ","pages":"Article 106872"},"PeriodicalIF":2.5000,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Does flaxseed supplementation affect apo-lipoproteins? A GRADE-assessed systematic review and meta-analysis\",\"authors\":\"Sasan Pourbagher Benam , Seyedsaber Mirabdali , Negar Ebrahimi , Maziar Daneshvar , Shima Vahedi , Fateme Abbasifard , Mahsa Rounagh\",\"doi\":\"10.1016/j.prostaglandins.2024.106872\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Several studies indicated the ameliorating effects of flaxseed supplementation on apolipoproteins, although others have conflicting results. Therefore, the present research was conducted in order to accurately and definitively understand the effect of flaxseed on apolipoproteins in adults. All articles published up to Juan 2024 were systematically searched through PubMed, Scopus, Embase, and Web of Science to collect all randomized clinical trials (RCTs). A random effects model was used to measure the combined effect sizes. Also, standardized mean difference (SMD) and 95 % confidence interval (CI) were used to report the combined effect size. Our results showed that flaxseed supplementation significantly reduced apo-BI (SMD: −0.57; 95 % CI: −0.95, −0.19, p = 0.003; <em>I</em><sup>2</sup> = 83.2 %, heterogeneity p < 0.001) and lipo(a) decreased (SMD: −0.34; 95 % CI: −0.59, −0.09, p=0.007; <em>I</em><sup>2</sup>=30.3 %, heterogeneity p=0.197). However, flaxseed did not change apo-AI levels (SMD: −0.37; 95 % CI: −0.87, 0.13, p = 0.146; <em>I</em><sup>2</sup> = 89.2 %, p-heterogeneity < 0.001). This meta-analysis has shown that flaxseed supplementation may have beneficial effects on apolipoproteins. Future high-quality, long-term clinical trials are needed to confirm our results.</p></div>\",\"PeriodicalId\":21161,\"journal\":{\"name\":\"Prostaglandins & other lipid mediators\",\"volume\":\"174 \",\"pages\":\"Article 106872\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins & other lipid mediators\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1098882324000662\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins & other lipid mediators","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1098882324000662","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
有几项研究表明，补充亚麻籽可改善脂蛋白，但其他研究结果却相互矛盾。因此，本研究旨在准确、明确地了解亚麻籽对成人脂蛋白的影响。研究人员通过PubMed、Scopus、Embase和Web of Science系统地检索了截至2024年发表的所有文章，收集了所有随机临床试验（RCT）。采用随机效应模型来衡量综合效应大小。此外，还使用了标准化平均差（SMD）和 95% 置信区间（CI）来报告综合效应大小。我们的研究结果表明，补充亚麻籽可显著降低载脂蛋白胆固醇（SMD：-0.57；95% CI：-0.95，-0.19，p=0.003；I2=83.2%，异质性 p <0.001），降低脂联素（a）（SMD：-0.34；95% CI：-0.59，-0.09，p=0.007；I2=30.3%，异质性 p=0.197）。然而，亚麻籽并没有改变载脂蛋白-AI的水平（SMD：-0.37；95% CI：-0.87，0.13，p=0.146；I2=89.2%，异质性p<0.001）。这项荟萃分析表明，补充亚麻籽可能会对脂蛋白产生有益影响。未来需要进行高质量的长期临床试验来证实我们的结果。
Does flaxseed supplementation affect apo-lipoproteins? A GRADE-assessed systematic review and meta-analysis
Several studies indicated the ameliorating effects of flaxseed supplementation on apolipoproteins, although others have conflicting results. Therefore, the present research was conducted in order to accurately and definitively understand the effect of flaxseed on apolipoproteins in adults. All articles published up to Juan 2024 were systematically searched through PubMed, Scopus, Embase, and Web of Science to collect all randomized clinical trials (RCTs). A random effects model was used to measure the combined effect sizes. Also, standardized mean difference (SMD) and 95 % confidence interval (CI) were used to report the combined effect size. Our results showed that flaxseed supplementation significantly reduced apo-BI (SMD: −0.57; 95 % CI: −0.95, −0.19, p = 0.003; I2 = 83.2 %, heterogeneity p < 0.001) and lipo(a) decreased (SMD: −0.34; 95 % CI: −0.59, −0.09, p=0.007; I2=30.3 %, heterogeneity p=0.197). However, flaxseed did not change apo-AI levels (SMD: −0.37; 95 % CI: −0.87, 0.13, p = 0.146; I2 = 89.2 %, p-heterogeneity < 0.001). This meta-analysis has shown that flaxseed supplementation may have beneficial effects on apolipoproteins. Future high-quality, long-term clinical trials are needed to confirm our results.
期刊介绍：
Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators.
Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology.
Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.
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