整合素在大脑健康和神经退行性疾病中的作用。

IF 4.5 3区生物学 Q2 CELL BIOLOGY

European journal of cell biology Pub Date : 2024-07-06 DOI:10.1016/j.ejcb.2024.151441

Yunhao Cui , Taisia Rolova , Susanna C. Fagerholm

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引用次数: 0

摘要

整合素是一种表达在大多数细胞表面的异二聚体膜蛋白。它们介导与包括神经系统发育和功能在内的大量生理过程相关的粘附和信号传导过程。有趣的是，整合素也是多发性硬化症等炎症性疾病的公认治疗靶点。在此，我们将讨论整合素在大脑发育和功能中的作用，以及在影响大脑的神经退行性疾病（阿尔茨海默病、多发性硬化症、中风）中的作用。此外，我们还讨论了针对这些粘附受体在脑部炎症疾病中的治疗作用。

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The role of integrins in brain health and neurodegenerative diseases

Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer’s disease, multiple sclerosis, stroke). Furthermore, we discuss therapeutic targeting of these adhesion receptors in inflammatory diseases of the brain.

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来源期刊

European journal of cell biology 生物-细胞生物学

CiteScore

7.30

自引率

1.50%

发文量

审稿时长

38 days

期刊介绍： The European Journal of Cell Biology, a journal of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and developmental biology are encouraged. Manuscripts describing significant technical advances are also welcome. In addition, papers dealing with biomedical issues of general interest to cell biologists will be published. Contributions addressing cell biological problems in prokaryotes and plants are also welcome.