肥胖引发的炎症：连接外周与大脑

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-07-12 DOI:10.1038/s42255-024-01079-8

Ophélia Le Thuc, Cristina García-Cáceres

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引用次数: 0

摘要

肥胖通常与影响全身的慢性、低度炎症状态有关。这种持续的炎症状态破坏了外周与大脑之间的协调沟通，而大脑在通过体液、营养介导、免疫和神经信号途径维持体内平衡方面起着至关重要的作用。肥胖引发的炎症性变化会特别影响沟通界面，包括血脑屏障、淋巴系统和脑膜。因此，第三脑室附近的脑区，包括下丘脑和其他与认知相关的区域，容易受到损伤，导致能量平衡失调和认知障碍（如阿尔茨海默病和痴呆症）风险升高。这篇综述探讨了大脑与外周之间错综复杂的交流，强调了肥胖引发的炎症对大脑功能的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Obesity-induced inflammation: connecting the periphery to the brain

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Obesity-induced inflammation: connecting the periphery to the brain

Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire body. This sustained inflammatory state disrupts the coordinated communication between the periphery and the brain, which has a crucial role in maintaining homeostasis through humoural, nutrient-mediated, immune and nervous signalling pathways. The inflammatory changes induced by obesity specifically affect communication interfaces, including the blood–brain barrier, glymphatic system and meninges. Consequently, brain areas near the third ventricle, including the hypothalamus and other cognition-relevant regions, become susceptible to impairments, resulting in energy homeostasis dysregulation and an elevated risk of cognitive impairments such as Alzheimer’s disease and dementia. This Review explores the intricate communication between the brain and the periphery, highlighting the effect of obesity-induced inflammation on brain function. Le Thuc and García-Cáceres discuss the effect of obesity-induced systemic inflammation on the brain, including hypothalamic circuits for whole-body energy homeostasis as well as cognitive function.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.