单细胞方法在免疫代谢和免疫毒理学中的应用

IF 4.6
Peer W.F. Karmaus
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引用次数: 0

摘要

新型单细胞分析技术的最新发展迅速推动了免疫毒理学和免疫代谢领域的进步。通过单细胞分析,可以描述免疫细胞的特征、揭示异质性以及细胞扰动(包括毒物损伤和细胞代谢变化)时的群体动态。本综述概述了当前的技术和最新发现,说明了单细胞分析在免疫毒理学和免疫代谢领域的新兴作用。文中讨论了各种单细胞技术,包括流式细胞仪、质控细胞仪、多重成像和测序,以及它们在免疫毒理学和免疫代谢研究中的应用。这篇综述强调了单细胞分析的潜力,它能彻底改变我们对免疫细胞异质性的认识,发现新的细胞治疗靶点,并为新的机理认识铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of single cell methods in immunometabolism and immunotoxicology

Recent developments of novel single-cell analysis techniques have rapidly advanced the fields of immunotoxicology and immunometabolism. Single-cell analyses enable the characterization of immune cells, unraveling heterogeneity, and population dynamics in response to cellular perturbations, including toxicant insults and changes in cellular metabolism. This review provides an overview of current technologies and recent discoveries, illustrating an emerging role of single-cell analyses in the field of immunotoxicology and immunometabolism. Various single-cell techniques, including flow cytometry, mass cytometry, multiplexed imaging, and sequencing, together with their applications to studying immunotoxicology and immunometabolism are discussed. This review emphasizes the potential for single-cell analyses to revolutionize our understanding of immune cell heterogeneity, uncover novel cellular therapeutic targets, and pave the way for novel mechanistic insights.

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来源期刊
Current opinion in toxicology
Current opinion in toxicology Toxicology, Biochemistry
CiteScore
8.50
自引率
0.00%
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0
审稿时长
64 days
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