富马酸-1通过PGC-1α调控线粒体稳态促进细胞凋亡并抑制甲状腺癌的进展

Xiaomei Meng, Dong You, Ruizhen Ren
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引用次数: 0

摘要

背景:甲状腺癌是一种罕见的癌症,但在全球范围内发病率越来越高。甲状腺癌的发生和发展与线粒体不稳定性有关,线粒体不稳定性是指线粒体的结构、功能和能量状态发生改变。这些改变导致线粒体代谢失衡,造成细胞损伤和凋亡。然而,线粒体不稳定性与甲状腺癌的分子机制仍鲜为人知:方法:本研究培养了人类甲状腺乳头状癌细胞系(TPC-1 和 K-1)和正常甲状腺细胞系(Nthy-ori 3-1)。分别用oveRNA-FH1和oveRNA-NC转染TPC-1细胞和K-1细胞,分别称为oveRNA-FH1组、oveRNA-NC组、TPC-1组和Nthy-ori 3-1组。实验采用多种方法评估细胞活力、增殖能力、侵袭和迁移能力以及线粒体形态变化和相关因子的表达。这些实验的目的是评估 FH1 对线粒体不稳定性的影响,并阐明甲状腺癌和线粒体不稳定性的具体机制:研究结果表明,与正常甲状腺细胞系相比,FH1在甲状腺乳头状癌细胞系中的表达明显下调。过表达 FH1 会降低 TPC-1 细胞的存活率并抑制细胞增殖率。此外,FH1 的过表达还抑制了细胞的侵袭和迁移能力。在 TPC-1 和 K-1 细胞中观察到异常的线粒体形态变化,而 FH1 过表达则导致线粒体相对正常。过表达 FH1 还会影响融合基因和裂变基因的表达,促进甲状腺癌细胞的裂变,抑制融合。此外,FH1 的过表达还导致炎症和裂解增加。这些结论在体外肿瘤形成实验中得到了进一步验证:结论:FH1通过PGC-1α依赖途径调节线粒体稳态,从而影响热凋亡和细胞凋亡,促进甲状腺癌的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Withdrawn: Fumarate-1 Mediates the Regulation of Mitochondrial Homeostasis by PGC-1α to Promote Cell Pyroptosis and Inhibit the Thyroid Cancer

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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