[感染性肠道/肝损伤中肠道与肝脏相互作用的作用和机制]。

Q3 Medicine
Hongyan Xiao, Huaping Liang, Junyu Zhu
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引用次数: 0

摘要

感染是当前常见的医学问题。不同的病原体会导致不同的感染。严重感染最终会导致败血症,造成多器官功能障碍,患者死亡率很高。因此,研究严重感染的发生和发展对提高患者的存活率至关重要。越来越多的研究揭示了肠道和肝脏之间的联系在感染性疾病中的重要作用。维持肠道机械屏障和生物屏障功能,调节肠道菌群代谢产物,可以减轻感染性肝损伤。胆汁酸是肝脏中的重要代谢产物,可抑制某些感染性肠道损伤的进展,促进某些病原体引起的肠道损伤。本文综述了肠肝轴在感染中的作用机制,以期为临床感染的治疗找到新的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Role and mechanism of intestinal-liver interaction in infectious intestinal/liver injury].

Infection is a common medical problem at present. Different pathogens can lead to different infections. Severe infections can ultimately lead to sepsis, resulting in multiple organ dysfunction and the high mortality of patients. Therefore, studying the occurrence and development of severe infections is essential to improve the survival rate of patients. More and more studies have revealed the important role of connection between intestine and liver in infectious diseases. The maintenance of intestinal mechanical barrier and biological barrier function and the regulation of intestinal flora metabolites can reduce infectious liver injury. Bile acids are important metabolites in the liver, which can inhibit the progression of certain infectious intestinal injuries and promote intestinal damage caused by certain pathogens. In this article, the mechanism of action of the intestinal-liver axis in infection was reviewed to find a new target for the treatment of clinical infection.

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来源期刊
Zhonghua wei zhong bing ji jiu yi xue
Zhonghua wei zhong bing ji jiu yi xue Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.00
自引率
0.00%
发文量
42
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