获得性再生障碍性贫血疗法:免疫抑制疗法与替代性供者造血细胞移植手术。

IF 1.3 Q4 HEMATOLOGY
Journal of hematology Pub Date : 2024-06-01 Epub Date: 2024-06-28 DOI:10.14740/jh1264
Baldeep Wirk
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引用次数: 0

摘要

对获得性重型再生障碍性贫血进行免疫抑制治疗可改善泛发性再生障碍性贫血,但有很大的复发风险(40%)和克隆演变为骨髓肿瘤的风险(15%),尤其是对40岁以上的患者。然而,目前针对40岁以上新诊断的重型再生障碍性贫血患者的指南建议采用免疫抑制疗法,而非治愈性异体干细胞移植。前期同种异体干细胞移植仅限于极少数不仅年轻而且有匹配兄弟姐妹供体的患者。本文将讨论改变实践的数据,这些数据涉及前期替代供者造血细胞移植的最新进展,可改写当前的治疗算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acquired Aplastic Anemia Therapies: Immunosuppressive Therapy Versus Alternative Donor Hematopoietic Cell Transplantation.

Immunosuppressive therapy for acquired severe aplastic anemia improves pancytopenia but has a significant risk of relapse (40%) and clonal evolution to myeloid neoplasms (15%), especially in patients older than 40. Yet, current guidelines for newly diagnosed severe aplastic anemia patients over the age of 40 recommend immunosuppressive therapy instead of curative allogeneic stem cell transplantation. Upfront allogeneic stem cell transplants are restricted to the rare patient who is not only young but also has a matched sibling donor. This article will discuss practice-changing data on the recent advances in upfront alternative donor hematopoietic cell transplants that could rewrite current treatment algorithms.

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来源期刊
Journal of hematology
Journal of hematology HEMATOLOGY-
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