体育锻炼对健康孕妇血脂和 HbA1c 的影响：FitMum 随机对照试验。

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2024-10-01 DOI:10.1016/j.eprac.2024.07.002

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引用次数: 0

摘要

目的孕期母体血脂和血糖浓度会影响胎儿的生长以及妊娠和分娩并发症的风险。我们旨在研究孕期体力活动（PA）对母体血脂和血红蛋白 A1c（HbA1c）浓度的影响。我们假设，较高的体力活动与血脂和血糖控制的改善有关：在一项随机对照试验的二次分析中，我们纳入了第 15+0 周前的 216 名孕妇，并测试了在整个孕期两种不同的 PA 干预方法与标准护理相比对孕妇血脂和 HbA1c 浓度的影响。此外，我们还调查了通过活动追踪器测量的 PA 本身的效果。总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL-C)、低密度脂蛋白胆固醇 (LDL-C)、甘油三酯和 HbA1c 的浓度分别在第 ≤15+0、28+0-6、34+0-6 周和分娩时（第 32+1 至 42+0 周）进行测量。分别使用线性混合效应模型和线性回归分析检验了干预措施和 PA 本身的效果：结果：未发现 PA 干预对孕期母体血脂或 HbA1c 有任何影响。在 PA 本身的分析中，随着妊娠的进展，每周进行更多分钟的中强度至高强度 PA 与 TC（-1.3E-04，p=0.020）和 LDL-C （-8.5E-05，p=0.035）的增加较少有关。更多的活跃千卡热量与较低的总胆固醇（-5.5E-05，P=0.035）的增加有关：虽然提供 PA 干预没有效果，但随着孕期的延长，较高的 PA 与总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的增加减少有关。

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Effects of Physical Activity on Blood Lipids and Hemoglobin A1c in Healthy Pregnant Women: The FitMum Randomized Controlled Trial

Objective

Maternal blood lipid and glucose concentrations during pregnancy affect fetal growth and the risk of pregnancy and delivery complications.

We aimed to investigate the effects of physical activity (PA) during pregnancy on maternal blood lipid and hemoglobin A1c (HbA1c) concentrations. We hypothesized that higher PA was associated with improved lipid profile and glycemic control.

Methods

In a secondary analysis of a randomized controlled trial, we included 216 pregnant women before week 15 + 0 and tested the effects of two different PA interventions throughout pregnancy compared to standard care on maternal blood lipid and HbA1c concentrations. Additionally, we investigated the effect of PA per se measured by an activity tracker. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride, and HbA1c concentrations were measured at week ≤15 + 0, 28+0-6, 34+0-6, and at delivery (week 32 + 1 to 42 + 0). Effects of the interventions and PA per se were tested using linear mixed effects models and linear regression analyses, respectively.

Results

No effects of the PA interventions were detected on maternal lipids or HbA1c during pregnancy. In PA per se analyses, more minutes per week of moderate-to-vigorous intensity PA were associated with less increase in TC (−1.3E-04, P = .020) and LDL-C (−8.5E-05, P = .035) as pregnancy progresses. More active kilocalories were associated with less increase in TC (−5.5E-05, P < .001), HDL-C (−9.5E-06, P = .024), and LDL-C (−3.2E-05, P = .005).

Conclusion

Whilst there were no effects of offering PA interventions, higher PA was associated with reduced increases in TC, HDL-C, and LDL-C as pregnancy progressed.

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.