{"title":"在温和条件下与不饱和糖基供体高度区域/全选择性合成碳水化合物","authors":"Xinyu Gao, Keke Ren, Lijuan Ma, Nengzhong Wang, Nianyu Huang, Hui Yao","doi":"10.1055/a-2348-2803","DOIUrl":null,"url":null,"abstract":"<p>Carbohydrates and their conjugates play important roles in life activities and drug development. Our group was committed to the general and effective glycosylation methods and their application in chemical biology using unsaturated glycosyl donors. In the past five years, we have reported several synthetic strategies with high stereoselectivity and milder conditions compared with previous works. In particular, high chemo-/regio- and stereoselective <i>O</i>-glycosylation, <i>C</i>-glycosylation and <i>S</i>-glycosylation could be achieved via palladium catalysis under open-air conditions at room temperature. In this Account, we will introduce our research progress in constructing four types of glycosides.</p> <p>1 Introduction</p> <p>2 Stereoselective Synthesis of <i>O</i>-Glycosides</p> <p>3 Stereoselective Synthesis of <i>C</i>-Glycosides</p> <p>4 Stereoselective Synthesis of <i>N</i>-Glycosides</p> <p>5 Stereoselective Synthesis of <i>S</i>-Glycosides</p> <p>6 Conclusion</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly Regio-/Stereoselective Synthesis of Carbohydrates with Unsaturated Glycosyl Donors under Mild Conditions\",\"authors\":\"Xinyu Gao, Keke Ren, Lijuan Ma, Nengzhong Wang, Nianyu Huang, Hui Yao\",\"doi\":\"10.1055/a-2348-2803\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Carbohydrates and their conjugates play important roles in life activities and drug development. Our group was committed to the general and effective glycosylation methods and their application in chemical biology using unsaturated glycosyl donors. In the past five years, we have reported several synthetic strategies with high stereoselectivity and milder conditions compared with previous works. In particular, high chemo-/regio- and stereoselective <i>O</i>-glycosylation, <i>C</i>-glycosylation and <i>S</i>-glycosylation could be achieved via palladium catalysis under open-air conditions at room temperature. In this Account, we will introduce our research progress in constructing four types of glycosides.</p> <p>1 Introduction</p> <p>2 Stereoselective Synthesis of <i>O</i>-Glycosides</p> <p>3 Stereoselective Synthesis of <i>C</i>-Glycosides</p> <p>4 Stereoselective Synthesis of <i>N</i>-Glycosides</p> <p>5 Stereoselective Synthesis of <i>S</i>-Glycosides</p> <p>6 Conclusion</p> \",\"PeriodicalId\":22319,\"journal\":{\"name\":\"Synlett\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synlett\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2348-2803\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synlett","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1055/a-2348-2803","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
摘要
碳水化合物及其共轭物在生命活动和药物开发中发挥着重要作用。我们的研究小组致力于利用不饱和糖基供体研究通用有效的糖基化方法及其在化学生物学中的应用。在过去的五年中，我们报道了几种具有高立体选择性的合成策略，与之前的工作相比，条件更加温和。特别是在室温露天条件下，通过钯催化实现了高化学/调节和立体选择性的 O-糖基化、C-糖基化和 S-糖基化。本报告将介绍我们在构建四种糖苷方面的研究进展。1 引言 2 立体选择性合成 O 型糖苷 3 立体选择性合成 C 型糖苷 4 立体选择性合成 N 型糖苷 5 立体选择性合成 S 型糖苷 6 结论
Highly Regio-/Stereoselective Synthesis of Carbohydrates with Unsaturated Glycosyl Donors under Mild Conditions
Carbohydrates and their conjugates play important roles in life activities and drug development. Our group was committed to the general and effective glycosylation methods and their application in chemical biology using unsaturated glycosyl donors. In the past five years, we have reported several synthetic strategies with high stereoselectivity and milder conditions compared with previous works. In particular, high chemo-/regio- and stereoselective O-glycosylation, C-glycosylation and S-glycosylation could be achieved via palladium catalysis under open-air conditions at room temperature. In this Account, we will introduce our research progress in constructing four types of glycosides.
期刊介绍：
SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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