MFTP-Tool: A Wide & Deep Learning Framework for Multi-Functional Therapeutic Peptides Prediction

Background: The identification and functional prediction of Multifunctional Therapeutic Peptides (MFTP) play a pivotal role in drug discovery, particularly for conditions such as inflammation and hyperglycemia. Current computational methods exhibit limitations in their ability to accurately predict the multifunctionality of these peptides. Methods: We propose a novel Wide and Deep Learning Framework that integrates both deep learning and machine learning approaches. The deep learning segment processes word vectors using a neural network model, while the wide segment utilizes the physicochemical properties of peptides in a random forest-based model. This hybrid approach aims to enhance the accuracy of MFTP function prediction. Results: Our framework outperformed the existing PrMFTP predictor in terms of precision, coverage, accuracy, and absolute true values. The evaluation was conducted on both training and independent testing datasets, demonstrating the robustness and generalizability of our model. Conclusion: The proposed Wide & Deep Learning Framework offers a significant advancement in the computational prediction of MFTP functions. The availability of our model through a userfriendly web interface at MFTP-Tool.m6aminer.cn provides a valuable tool for researchers in the field of therapeutic peptide-based drug discovery, potentially accelerating the development of new treatments.