骨髓脂肪组织是绝经后骨质疏松症的关键调节因子--简明综述

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-07-11 DOI:10.2147/cia.s466446

Huifang Niu, Minfeng Zhou, Xiaoyun Xu, Xiaojuan Xu

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引用次数: 0

摘要

摘要：绝经后骨质疏松症（PMOP）是影响全球数百万妇女健康的主要问题。绝经后骨质疏松症患者通常伴有骨髓脂肪组织（BMAT）的异常堆积。骨髓脂肪组织是骨平衡的重要调节器，骨髓脂肪组织体积的增加与骨量减少或骨折呈负相关。BMAT 通过脂肪因子、细胞因子和免疫系统调节骨代谢，但具体机制尚不清楚。本综述强调了雌激素缺乏对骨稳态和骨髓脂肪组织膨胀的影响，以及骨髓脂肪组织调节绝经后骨质疏松症的机制，为针对骨髓脂肪组织预防和治疗绝经后骨质疏松症提供了一种有前景的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bone Marrow Adipose Tissue as a Critical Regulator of Postmenopausal Osteoporosis - A Concise Review

Abstract: Postmenopausal osteoporosis (PMOP) is a major health problem affecting millions of women worldwide. PMOP patients are often accompanied by abnormal accumulation of bone marrow adipose tissue (BMAT). BMAT is a critical regulator of bone homeostasis, and an increasing BMAT volume is negatively associated with bone mass reduction or fracture. BMAT regulates bone metabolism via adipokines, cytokines and the immune system, but the specific mechanisms are largely unknown. This review emphasizes the impact of estrogen deficiency on bone homeostasis and BMAT expansion, and the mechanism by which BMAT regulates PMOP, providing a promising strategy for targeting BMAT in preventing and treating PMOP.

Keywords: postmenopausal osteoporosis, bone marrow adipose tissue, bone metabolism, immune system, cytokines

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.