结核分枝杆菌的抗药性机制

IF 0.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Genetics, Microbiology and Virology Pub Date : 2024-07-09 DOI:10.3103/s0891416824700010

M. V. Shulgina

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引用次数: 0

摘要

摘要本综述介绍了对长期使用的抗结核药物和新型抗结核药物作用机制的研究结果，以及有关新型化合物作为潜在抗结核药物的信息。文中还提供了与细菌耐药性有关或导致细菌耐药性的一些感染基因突变的数据。本综述包括 67 篇出版物、系统综述和电子数据库的成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanisms of Mycobacterium tuberculosis Drug Resistance

Abstract

The review presents the results of investigations of the mechanisms of action of long-used and new antituberculosis drugs, and information about new chemical compounds as potential antituberculosis drugs. Data are given on mutations in a number of infectant genes associated with or leading to bacterial resistance to these drugs. The review comprises the results of 67 publications, systematic reviews, and electronic databases.

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来源期刊

Molecular Genetics, Microbiology and Virology BIOCHEMISTRY & MOLECULAR BIOLOGY-MICROBIOLOGY

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Genetics, Microbiology and Virology is a journal that covers most topical theoretical and applied problems of molecular genetics of pro- and eukaryotic organisms, molecular microbiology and molecular virology. An important part the journal assigns to investigations of the genetic apparatus of microorganisms, searching for forms of genetic exchange, genetic mapping of pathogenic causative agents, to ascertainment of the structure and functions of extrachromosomal factors of heredity and migratory genetic elements, to theoretical studies into the mechanisms of genetic regulation. The journal publishes results of research on molecular and genetic bases of an eukaryotic cell, functioning of chromosomes and chromatin, nature of genetic changes in malignization and a set of hereditary diseases. On the pages of the journal there is covered the formulation of molecular bases of virology including issues of integration of viral and cellular genomes, and issues of persistence. The journal plans to put materials on genetic engineering, envisaging synthesis and isolation of genes from natural reservoirs, creation of plasmid- and virus-based vector, production of recombinant DNA molecules, the creation of Gene Banks for Microbes, animals, and human; and also on biotechnological production of hormones, components of antiviral vaccines, diagnostic and therapeutic preparations.