利用弥散核磁共振成像预测白质的中观拉莫尔频率偏移--一项模拟蒙特卡洛研究

arXiv - PHYS - Medical Physics Pub Date : 2024-07-09 DOI:arxiv-2407.06694

Anders Dyhr Sandgaard, Sune Nørhøj Jespersen

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摘要

本研究旨在验证核磁共振成像能否测量白质轴突微结构相对于 B0 方向的各向异性中观拉莫尔频率偏移，以及 dMRI 能否估计这种各向异性。最近的模型描述了介观拉莫尔频率偏移如何取决于轴突的诱导磁场，轴突的诱导磁场由方向分布函数描述。通过对中观白质轴突基质中的磁共振成像信号进行蒙特卡洛模拟，我们发现磁共振成像可以估计这种中观频移，而 dMRI 可以估计其方向依赖性。

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Predicting Mesoscopic Larmor Frequency Shifts in White Matter with Diffusion MRI -- An In-Silico Monte-Carlo Study

This study aims to validate if MRI can measure anisotropic mesoscopic Larmor frequency shifts from white matter axonal microstructure relative to the B0 direction and if dMRI can estimate this anisotropy. Recent models describe how mesoscopic Larmor frequency shifts depend on induced magnetic fields by axons, described by an orientation distribution function. Using Monte-Carlo simulations of MRI signals in mesoscopic white matter axon substrates, we show MRI can estimate this mesoscopic frequency shift and dMRI can estimate its orientation dependence.

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arXiv - PHYS - Medical Physics

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