Alexandr Mandzhulo, Iryna Vashchenko, Oleg Lukin, Svetlana Shishkina, Grygoriy Dolgonos, Andrii Gerasov, Vitaliy Yepishev, Dariia Samofalova, Volodymyr Fetyukhin, Alexander Shivanyuk
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Spirocyclic Hybrids of Nortropane and 1,3-Oxazinan-2-one Fragments
We report facile and versatile procedures for the synthesis of exo- and endo-isomeric spirocyclic hybrids of pharmacophoric (1R,5S)-8-azabicyclo[3.2.1]octane (nortropane) and 1,3-oxazinan-2-one fragments. Our approach consists of the hydrocyanation of endo- and exo-isomeric N-Cbz-protected nortropane-3-spiroepoxides, the reduction of hydroxy nitriles into amino alcohols, the synthesis of N-alkylated amino alcohols via reductive amination, the spirocyclization of the amino alcohols, N-alkylation of the unsubstituted 1,3-oxazinan-2-one fragment in the spiro compounds, and removal of the Cbz protecting groups.
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