mRNA3'末端的主调控因子CPSF对多种生物过程的调节作用

IF 4.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

RNA Pub Date : 2024-07-10 DOI:10.1261/rna.080108.124

Lizhi Liu, James L. Manley

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引用次数: 0

摘要

裂解和多腺苷酸化特异性因子（CPSF）复合物在 mRNA 3'末端的形成过程中起着核心作用，它负责识别多聚（A）信号序列、核酸内切裂解步骤以及招募多聚（A）聚合酶。三十多年来，人们对 CPSF 进行了广泛的研究，其功能及其各个亚基的功能也越来越明确，目前的研究主要集中在这些蛋白对细胞正常功能或疾病/应激状态的影响上。在这篇综述中，我们将概述 CPSF 及其亚基的一般功能，然后讨论它们如何在令人惊讶的各种生物过程和细胞条件中发挥其功能。其中包括转录终止、小 RNA 处理和 R 环预防/解决，以及更广泛的癌症、分化/发育和感染/免疫。

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Modulation of diverse biological processes by CPSF, the master regulator of mRNA 3’ ends

The Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays a central role in the formation of mRNA 3’ ends, being responsible for recognition of the poly(A) signal sequence, the endonucleolytic cleavage step, and recruitment of poly(A) polymerase. CPSF has been extensively studied for over three decades, and its functions and those of its individual subunits are becoming increasingly well-defined, with much current research focusing on the impact of these proteins on the normal functioning or disease/stress states of cells. In this review, we provide an overview of the general functions of CPSF and its subunits, followed by discussion of how they exert their functions in a surprisingly diverse variety of biological processes and cellular conditions. These include transcription termination, small RNA processing and R-loop prevention/resolution, as well as more generally cancer, differentiation/development and infection/immunity.

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来源期刊

RNA 生物-生化与分子生物学

CiteScore

8.30

自引率

2.20%

发文量

101

审稿时长

2.6 months

期刊介绍： RNA is a monthly journal which provides rapid publication of significant original research in all areas of RNA structure and function in eukaryotic, prokaryotic, and viral systems. It covers a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; alternative processing: cis-acting elements and trans-acting factors; ribosome structure and function; translational control; RNA catalysis; tRNA structure, function, biogenesis and identity; RNA editing; rRNA structure, function and biogenesis; RNA transport and localization; regulatory RNAs; large and small RNP structure, function and biogenesis; viral RNA metabolism; RNA stability and turnover; in vitro evolution; and RNA chemistry.