模拟重合损失对成像应用中计数探测器计数率统计和噪声性能的影响

IF 1.9 3区 物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY
P. Zambon
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引用次数: 0

摘要

重合损失会对像素化计数探测器提供的图像质量产生不利影响,尤其是在低温电子显微镜等对剂量敏感的应用中,因为在这些应用中需要最大限度地从记录的信号中提取信息。在这项工作中,我们研究了重合损失现象对产生稀疏二值图像的计数探测器中记录的统计数据的影响。首先,我们推导出记录计数的均值和方差的精确分析表达式,并将其作为传入事件率的函数。其次,我们要解决记录事件(即识别为单个传入事件的像素集群)的均值和方差问题,这也是传入事件率的函数。在此框架下,我们回顾了以往不同学科对近似二维模型的研究,并根据我们的情况对其进行了批判性的重新解释,同时评估了在当前情况下采用这些模型的适宜性。通过了解记录统计量的前两个矩,可以推断信噪比(SNR)和零频率时的探测量子效率(DQE0)。分析结果通过与定制蒙特卡洛代码获得的数值数据进行比较得到验证。我们为低温电子显微镜应用选择了一个实际案例研究,它由一个 25 微米厚的 MAPS 探测器组成,像素尺寸为 10 微米,在很宽的入射率范围内用 300 千伏能量的电子照射。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modeling the impact of coincidence loss on count rate statistics and noise performance in counting detectors for imaging applications
Coincidence loss can have detrimental effects on the image quality provided by pixelated counting detectors, especially in dose-sensitive applications like cryoEM where the information extracted from the recorded signal needs to be maximized. In this work, we investigate the impact of coincidence loss phenomena on the recorded statistics in counting detectors producing sparse binary images. First, we derive exact analytical expressions for the mean and the variance of the recorded counts as a function of the incoming event rate. Second, we address the problem of the mean and variance of the recorded events (i.e., pixel clusters identified as individual incoming events), which also acts as a function of the incoming event rate. In this frame, we review previous studies from different disciplines on approximated two-dimensional models, and we critically reinterpret them in our context and evaluate the suitability of their adoption in the present case. The knowledge of the first two momenta of the recorded statistics allows inferring about the signal-to-noise ratio (SNR) and the detective quantum efficiency at zero frequency (DQE0). Analytical results are validated through comparison with numerical data obtained with a custom-made Monte Carlo code. We chose a realistic case study for cryoEM application consisting of a 25-µm-thick MAPS detector featuring a pixel size of 10 µm and illuminated with electrons of 300 keV energy over a wide range of incoming rate.
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来源期刊
Frontiers in Physics
Frontiers in Physics Mathematics-Mathematical Physics
CiteScore
4.50
自引率
6.50%
发文量
1215
审稿时长
12 weeks
期刊介绍: Frontiers in Physics publishes rigorously peer-reviewed research across the entire field, from experimental, to computational and theoretical physics. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, engineers and the public worldwide.
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