预后营养指数 (PNI):腹部手术患者术前评估的潜在生物标志物

IF 0.4 4区 医学 Q4 SURGERY
Aritra Bhattacharjee, K. Bhuyan
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引用次数: 0

摘要

预后营养指数(PNI1)已被广泛用于预测胃肠道恶性肿瘤患者的手术风险。本研究的目的是评估 PNI 值,以预测各类腹部手术的结果,从而确定高危患者,避免发病率和死亡率。这项前瞻性研究纳入了 100 名急诊和择期接受腹部手术治疗的患者,年龄在 10-80 岁之间,男女不限。每位患者的 PNI 计算公式为:10 × 白蛋白(克/分升)+ 0-005 × 淋巴细胞总数(每立方毫米)。患者被分为低 PNI 组(PNI < 45)和高 PNI 组(PNI > 45)。采用卡方检验或费雪精确检验进行统计分析,P值在0.05以下为差异显著。发现女性患者的 PNI 水平较低(P 值为 0.017)。在 PNI 低的患者中,并发症的发生率较高(P 值为 0.001)。PNI<45组中需要重症监护室护理的患者更多(p值为0.021)。发现 PNI < 45 组的住院时间(p 值 0.001)和死亡率较高(p 值 0.016)。研究发现,PNI 是一种简单而有用的生物标志物,可确定腹部手术的基线风险并预测术后并发症和长期预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prognostic Nutritional Index (PNI): a Potential Biomarker For Preoperative Evaluation of Patients Undergoing Abdominal Surgery

Prognostic Nutritional Index (PNI): a Potential Biomarker For Preoperative Evaluation of Patients Undergoing Abdominal Surgery

The prognostic nutritional index (PNI1) has been widely used for the prediction of surgical risk in patients with gastrointestinal malignancy. The aim of this study was to evaluate PNI values to predict the outcome in various categories of abdominal surgery with the objective of identifying the patients at risk in order to avoid morbidity and mortality. One hundred patients undergoing surgical interventions for abdominal conditions both in emergency and elective settings in the age group of 10–80 years of either sex were included in this prospective study. The PNI of each patient was calculated as 10 × albumin (g/dl) + 0·005 × total lymphocyte count (per mm3). The patients were grouped into low PNI (PNI < 45) and high PNI (PNI > 45) groups. The chi-square test or Fisher exact test was applied for statistical analysis and a p-value of < 0.05 was considered significant. The PNI level was found to be low in female patients (p-value 0.017). There was a high incidence of co-morbidities amongst patients with low PNI (p-value 0.001). More patients in the PNI < 45 group needed ICU care (p-value 0.021). The length of hospital stays (p-value 0.001) and the mortality rate were found to be high (p-value 0.016) in the PNI < 45 group. The PNI has been found to be a simple and useful biomarker which can define the baseline risk and predict postoperative complications and long-term outcomes in abdominal surgery.

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来源期刊
CiteScore
0.60
自引率
25.00%
发文量
412
审稿时长
6-12 weeks
期刊介绍: The Indian Journal of Surgery is the official publication of the Association of Surgeons of India that considers for publication articles in all fields of surgery. Issues are published bimonthly in the months of February, April, June, August, October and December. The journal publishes Original article, Point of technique, Review article, Case report, Letter to editor, Teachers and surgeons from the past - A short (up to 500 words) bio sketch of a revered teacher or surgeon whom you hold in esteem and Images in surgery, surgical pathology, and surgical radiology. A trusted resource for peer-reviewed coverage of all types of surgery Provides a forum for surgeons in India and abroad to exchange ideas and advance the art of surgery The official publication of the Association of Surgeons of India 92% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again The Indian Journal of Surgery offers peer-reviewed coverage of all types of surgery. The Journal publishes Original articles, Points of technique, Review articles, Case reports, Letters, Images and brief biographies of influential teachers and surgeons. The Journal spans General Surgery, Pediatric Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Rural Surgery, Orthopedic Surgery, Urology, Surgical Oncology, Radiology, Anaesthesia, Trauma Services, Minimal Access Surgery, Endocrine Surgery, GI Surgery, ENT, Colorectal Surgery, surgical practice and research. The Journal provides a forum for surgeons from India and abroad to exchange ideas, to propagate the advancement of science and the art of surgery and to promote friendship among surgeons in India and abroad. This has been a trusted platform for surgons in communicating up-to-date scientific informeation to the community.
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