基于 2,2'-联吡啶和 1,10-菲罗啉的铜(ii)配合物作为开发抗肿瘤药物的潜在对象

IF 1.2 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Structural Chemistry Pub Date : 2024-07-09 DOI:10.1134/s0022476624060088

Yu. A. Golubeva, E. V. Lider

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引用次数: 0

摘要

摘要本文主要介绍基于 2,2′-联吡啶/1,10-菲罗啉和多种 N-、O-、S-配体的铜配位化合物，这些化合物具有细胞毒性。因此，它们可以作为开发抗肿瘤药物的起始平台。综述涵盖了这些复合物的结构、细胞毒性活性特征及其机制，以及体内研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper(ii) Complexes Based on 2,2’-Bipyridine and 1,10-Phenanthroline as Potential Objects for Developing Antitumor Drugs

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Copper(ii) Complexes Based on 2,2’-Bipyridine and 1,10-Phenanthroline as Potential Objects for Developing Antitumor Drugs

Abstract

The review is devoted to copper coordination compounds based on 2,2′-bipyridine / 1,10-phenanthroline and diverse N-, O-, S-donor ligands exhibiting cytotoxic properties. Therefore, they can be a starting platform for developing antitumor drugs. The review covers the structural aspects of the complexes, the features of their cytotoxic activity and its mechanism, as well as in vivo studies.

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来源期刊

Journal of Structural Chemistry 化学-无机化学与核化学

CiteScore

1.60

自引率

12.50%

发文量

142

审稿时长

8.3 months

期刊介绍： Journal is an interdisciplinary publication covering all aspects of structural chemistry, including the theory of molecular structure and chemical bond; the use of physical methods to study the electronic and spatial structure of chemical species; structural features of liquids, solutions, surfaces, supramolecular systems, nano- and solid materials; and the crystal structure of solids.