2014-2020 年间西班牙免疫性血小板减少症的流行病学、治疗模式和成本分析:基于人口的研究。

TH open : companion journal to thrombosis and haemostasis Pub Date : 2024-07-08 eCollection Date: 2024-07-01 DOI:10.1055/a-2336-1062
Tomás J González-López, Gabriela Alperovich, Elena Burillo, Marta Espejo-Saavedra Soler, Elena Rebollo-Gómez, Ignacio Hernández, Jose L Justicia, María L Lozano
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引用次数: 0

摘要

背景 免疫性血小板减少症(ITP)的特点是血小板计数低,经常导致出血、疲劳和与健康相关的生活质量下降。方法 这项基于人群的观察性、回顾性研究使用 BIG-PAC® 数据库,纳入了 2014 年至 2020 年间在基层医疗机构和医院确诊的西班牙儿科和成人原发性 ITP 患者(中位随访时间:4 年)。研究分析了流行病学、基线/临床特征、治疗趋势、医疗资源和成本。结果 BIG-PAC® 数据库包含 1,818,588 名患者的记录;170 名成人和 27 名儿童 ITP 患者纳入了我们的分析。据估计,每 100,000 人中的 ITP 患病率和年发病率分别为 10.8 人(慢性 ITP [cITP] 患者为 2.8 人)和 1.5 人(cITP 患者为 0.3 人)。鼻衄是最常见的出血事件,其次是泌尿生殖系统出血和胃肠道出血;>50%/>75%的 ITP/cITP 患者报告有疲劳感。慢性病患者基线血小板计数较低,需要更多的输血。皮质类固醇、免疫抑制剂和血小板生成素受体激动剂分别是一线、二线和三线治疗中使用最多的药物。35 名患者接受了脾脏切除术,他们都处于慢性期。患者平均每年分别在初级保健科、血液科/内科和急诊科就诊 13.9 次、6.6 次和 1.2 次。超过四分之一的成年患者平均每年请病假 16.3 天。年平均医疗总费用为 10,741 欧元(ITP 患者)和 19,809 欧元(cITP 患者)。结论 这是第一项从流行病学、治疗趋势、医疗资源和成本等方面对西班牙 ITP 患者状况进行全面透视的研究,突出强调了未得到满足的患者需求,以及 2014 年至 2020 年期间的直接和间接成本/资源使用情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology, Treatment Patterns, and Cost Analysis of Immune Thrombocytopenia in Spain between 2014 and 2020: A Population-based Study.

Background  Immune thrombocytopenia (ITP) is characterised by low platelet counts and often leads to bleeding, fatigue, and reduced health-related quality of life. Methods  This observational, retrospective, population-based study using BIG-PAC® database included Spanish paediatric and adult patients with primary ITP diagnosed in primary care and hospitals between 2014 and 2020 (median follow-up: 4 years). Epidemiology, baseline/clinical characteristics, treatment trends, healthcare resources and costs were analysed. Results  The BIG-PAC® database contains records of 1,818,588 patients; 170 adults and 27 children with ITP were included in our analysis. ITP prevalence and annual incidence per 100,000 were estimated in 10.8 (2.8 in chronic ITP [cITP] patients) and 1.5 (0.3 in cITP patients), respectively. Epistaxis was the most common bleeding event, followed by genitourinary and gastrointestinal bleeding; >50%/> 75% of ITP/cITP patients reported fatigue. Chronic patients had lower platelet counts at baseline and required more transfusions. Corticosteroids, immunosuppressants, and thrombopoietin receptor agonists were the most used agents in first-, second- and third-line treatment, respectively. Thirty-five patients, all of them in chronic phase, underwent splenectomy. Patients had on average 13.9, 6.6, and 1.2 visits/year to primary care, haematology/internal medicine, and emergency departments, respectively. More than one-fourth of adult patients took on average 16.3 days of sick leave annually. Mean annual total health care costs were €10,741 (ITP patients) and €19,809 (cITP patients). Conclusion  This is the first study to provide an overall perspective on the situation of the Spanish ITP population in terms of epidemiology, treatment trends, health care resources and costs, highlighting unmet patient needs, and direct and indirect costs/resource use between 2014 and 2020.

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