Jared Bradley, Ian Whitaker, Brittany Lyons, Amy Mangla
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引用次数: 0
摘要
简介免疫球蛋白 A 血管炎(IgA)是一种罕见疾病,以可触及的紫癜为特征,常累及皮肤、胃肠道、关节和肾脏。发病通常较急,多见于东南亚和欧洲血统的儿童和青少年。在成年人群中,这种疾病并不常见,治疗方法也不成熟:在东南亚和欧洲以外的人群中,IgA 血管炎的发病率还没有得到很好的记录。在本病例系列中,我们介绍了 2 例 IgA 血管炎病例,患者均为 2 名成年男性,其中 1 人是美国原住民后裔,1 人是非裔美国人后裔:结论:IgA 血管炎必须在成年人群中加以考虑,它并不局限于某些种族群体。要明确成人 IgA 血管炎患者的最佳治疗方案,还需要进一步的研究。我们认为,IgA 血管炎患者最好接受多学科治疗,尤其是那些使用皮质类固醇后病情仍无明显好转的患者。我们的两个病例应提高人们对皮疹和肌酐水平升高的 IgA 血管炎患者的认识。
Introduction: Immunoglobulin A vasculitis (IgA)is a rare condition characterized by palpable purpura, often involving the skin, gastrointestinal tract, joints, and kidneys. Presentation is usually acute and is more common in children and adolescents of Southeast Asian and European descent. In the adult population, it is less common and therapies are not as well-established.
Case presentation: Disease prevalence of IgA vasculitis outside Southeast Asian and European populations is not well-documented. In this case series, we present 2 cases of IgA vasculitis in 2 older adult males, one of Native American descent and one of African American descent.
Conclusion: IgA vasculitis must be considered within the adult population, and it is not limited to certain ethnic groups. Further research is needed to give clarity on the best treatment options for adults with IgA vasculitis. We believe that patients presenting with IgA vasculitis are best managed in a multidisciplinary approach, especially those patients with limited improvement despite the initiation of corticosteroids. Our 2 cases should raise awareness of IgA vasculitis in patients with skin rashes and elevated creatinine levels.