为 TGF-β1 紧身衣提供更多魔术贴：一种新型抗体将潜伏的 TGF-β1 绑在基质上。

IF 6.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Science Signaling Pub Date : 2024-07-09 DOI:10.1126/scisignal.ado5279

Boris Hinz

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引用次数: 0

摘要

在本期《科学信号》（Science Signaling）杂志上，杰克逊（Jackson）等人提出了一种新的抗体策略，可以将转化生长因子-β1（TGF-β1）与细胞外基质中的潜伏复合物紧密结合。这种抗体对免疫细胞表面潜伏的 TGF-β1 没有影响，因此可以在不影响 TGF-β1 有利的免疫抑制活性的情况下，针对纤维化中 TGF-β1 的有害影响进行治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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More Velcro for the TGF-β1 straitjacket: A new antibody straps latent TGF-β1 to the matrix

In this issue of Science Signaling, Jackson et al. present a new antibody strategy to—quite literally—strap transforming growth factor–β1 (TGF-β1) to latent complexes in the extracellular matrix. The antibody has no effect on latent TGF-β1 presented on the surface of immune cells and thus allows targeting of the detrimental effects of TGF-β1 in fibrosis without affecting its beneficial immune-suppressing activities.

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来源期刊

Science Signaling BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

9.50

自引率

0.00%

发文量

148

审稿时长

3-8 weeks

期刊介绍： "Science Signaling" is a reputable, peer-reviewed journal dedicated to the exploration of cell communication mechanisms, offering a comprehensive view of the intricate processes that govern cellular regulation. This journal, published weekly online by the American Association for the Advancement of Science (AAAS), is a go-to resource for the latest research in cell signaling and its various facets. The journal's scope encompasses a broad range of topics, including the study of signaling networks, synthetic biology, systems biology, and the application of these findings in drug discovery. It also delves into the computational and modeling aspects of regulatory pathways, providing insights into how cells communicate and respond to their environment. In addition to publishing full-length articles that report on groundbreaking research, "Science Signaling" also features reviews that synthesize current knowledge in the field, focus articles that highlight specific areas of interest, and editor-written highlights that draw attention to particularly significant studies. This mix of content ensures that the journal serves as a valuable resource for both researchers and professionals looking to stay abreast of the latest advancements in cell communication science.