[中毒的体外治疗]。

IF 1.3 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Gerald Hackl, Nikolaus Schreiber
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引用次数: 0

摘要

在极少数情况下,中毒患者可能需要使用体外程序来加强毒素清除。中毒体外治疗(EXTRIP)工作组就在危重中毒患者的治疗中使用体外治疗程序提出了基于共识和证据的建议,并不断进行更新。对于分布容积小、血浆蛋白结合率低、水溶性高的低分子量物质,体外清除率最高。为了最大限度地发挥体外清除作用,血液和透析液流速应尽可能高,并应使用表面积最大的膜。间歇性血液透析是最常用的体外程序,因为其效果最佳,而血液动力学受损的患者则可从持续程序中获益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Extracorporeal treatment in poisoning].

In rare cases, intoxicated patients may require an extracorporeal procedure for enhanced toxin elimination. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup provides consensus- and evidence-based recommendations regarding the use of extracorporeal procedures in the management of critically ill, poisoned patients, with ongoing updates. Extracorporeal clearance is highest for low molecular weight substances with low volume of distribution, low plasma protein binding, and high water-solubility. To maximize the effect of extracorporeal clearance, blood and dialysate flow rates should be as high as possible, and the membrane with the largest surface area should be utilized. Intermittent hemodialysis is the most commonly employed extracorporeal procedure due to its highest effectiveness, while hemodynamically compromised patients can benefit from a continuous procedure.

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来源期刊
CiteScore
2.60
自引率
9.10%
发文量
93
审稿时长
6-12 weeks
期刊介绍: Medizinische Klinik – Intensivmedizin und Notfallmedizin is an internationally respected interdisciplinary journal. It is intended for physicians, nurses, respiratory and physical therapists active in intensive care and accident/emergency units, but also for internists, anesthesiologists, surgeons, neurologists, and pediatricians with special interest in intensive care medicine. Comprehensive reviews describe the most recent advances in the field of internal medicine with special focus on intensive care problems. Freely submitted original articles present important studies in this discipline and promote scientific exchange, while articles in the category Photo essay feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. In the rubric journal club well-respected experts comment on outstanding international publications. Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice. The rubrics "Nursing practice" and "Physical therapy" round out the information.
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