Ritika Rampal, Stacey Jessica Jones, Sue Hartup, Clare Robertson, Wasif Tahir, Sian Louise Jones, Shireen McKenzie, Jessica Anne Savage, Baek Kim
{"title":"PROM-Q研究的三个月和十二个月分析：使用BREAST-Q问卷对胸大肌下植入假体前和胸大肌下植入假体后即刻乳房重建的患者报告结果进行比较。","authors":"Ritika Rampal, Stacey Jessica Jones, Sue Hartup, Clare Robertson, Wasif Tahir, Sian Louise Jones, Shireen McKenzie, Jessica Anne Savage, Baek Kim","doi":"10.1007/s10549-024-07416-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Implant-based breast reconstruction (IBR) is being increasingly performed with implant placed above the pectoral muscle (pre-pectoral), instead of below the pectoral muscle (sub-pectoral). Currently, there is a lack of comparative data on clinical and patient-perceived outcomes between pre- vs. sub-pectoral IBR. We investigated whether this difference in surgical approach influenced clinical or patient-perceived outcomes.</p><p><strong>Methods: </strong>This prospective non-randomised longitudinal cohort study (ClinicalTrials.gov identifier: NCT04842240) recruited patients undergoing immediate IBR at the Leeds Breast Unit (Sep 2019-Sep 2021). Data collection included patient characteristics and post-operative complications. Patient-Reported Outcome Measures were collected using the BREAST-Q questionnaire at baseline, 2 weeks, 3- and 12-months post-surgery.</p><p><strong>Results: </strong>Seventy-eight patients underwent IBR (46 patients pre-pectoral; 59% vs. 32 patients sub-pectoral; 41%). Similar complication rates were observed (15.2% pre-pectoral vs. 9.4% sub-pectoral; p = 0.44). Overall implant loss rate was 3.8% (6.5% pre-pectoral vs. 0% sub-pectoral; p = 0.13). Respective median Breast-Q scores for pre- and sub-pectoral IBR at 3 months were: breast satisfaction (58 vs. 48; p = 0.01), psychosocial well-being (60 vs. 57; p = 0.9), physical well-being (68 vs. 76; p = 0.53), and Animation Q scores (73 vs. 76; p = 0.45). Respective Breast-Q scores at 12 months were: breast satisfaction (58 vs. 53; p = 0.3), psychosocial well-being (59 vs. 60; p = 0.9), physical well-being (68 vs. 78; p = 0.18), and Animation Q scores (69 vs. 73; p = 0.4).</p><p><strong>Conclusions: </strong>This study demonstrates equivalent clinical and patient-perceived outcomes between pre- and sub-pectoral IBR. The study findings can be utilised to aid informed decision making regarding either surgical option.</p>","PeriodicalId":9133,"journal":{"name":"Breast Cancer Research and Treatment","volume":" ","pages":"275-282"},"PeriodicalIF":3.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Three and twelve-month analysis of the PROM-Q study: comparison of patient-reported outcome measures using the BREAST-Q questionnaire in pre- vs. sub-pectoral implant-based immediate breast reconstruction.\",\"authors\":\"Ritika Rampal, Stacey Jessica Jones, Sue Hartup, Clare Robertson, Wasif Tahir, Sian Louise Jones, Shireen McKenzie, Jessica Anne Savage, Baek Kim\",\"doi\":\"10.1007/s10549-024-07416-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Implant-based breast reconstruction (IBR) is being increasingly performed with implant placed above the pectoral muscle (pre-pectoral), instead of below the pectoral muscle (sub-pectoral). Currently, there is a lack of comparative data on clinical and patient-perceived outcomes between pre- vs. sub-pectoral IBR. We investigated whether this difference in surgical approach influenced clinical or patient-perceived outcomes.</p><p><strong>Methods: </strong>This prospective non-randomised longitudinal cohort study (ClinicalTrials.gov identifier: NCT04842240) recruited patients undergoing immediate IBR at the Leeds Breast Unit (Sep 2019-Sep 2021). Data collection included patient characteristics and post-operative complications. Patient-Reported Outcome Measures were collected using the BREAST-Q questionnaire at baseline, 2 weeks, 3- and 12-months post-surgery.</p><p><strong>Results: </strong>Seventy-eight patients underwent IBR (46 patients pre-pectoral; 59% vs. 32 patients sub-pectoral; 41%). Similar complication rates were observed (15.2% pre-pectoral vs. 9.4% sub-pectoral; p = 0.44). Overall implant loss rate was 3.8% (6.5% pre-pectoral vs. 0% sub-pectoral; p = 0.13). Respective median Breast-Q scores for pre- and sub-pectoral IBR at 3 months were: breast satisfaction (58 vs. 48; p = 0.01), psychosocial well-being (60 vs. 57; p = 0.9), physical well-being (68 vs. 76; p = 0.53), and Animation Q scores (73 vs. 76; p = 0.45). Respective Breast-Q scores at 12 months were: breast satisfaction (58 vs. 53; p = 0.3), psychosocial well-being (59 vs. 60; p = 0.9), physical well-being (68 vs. 78; p = 0.18), and Animation Q scores (69 vs. 73; p = 0.4).</p><p><strong>Conclusions: </strong>This study demonstrates equivalent clinical and patient-perceived outcomes between pre- and sub-pectoral IBR. 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引用次数: 0
摘要
目的：越来越多的植入式乳房重建（IBR）手术将植入物放置在胸大肌上方（胸大肌前），而不是胸大肌下（胸大肌下）。目前，还缺乏胸大肌前与胸大肌下 IBR 的临床和患者感知结果的比较数据。我们研究了手术方法的差异是否会影响临床或患者感知的结果：这项前瞻性非随机纵向队列研究（ClinicalTrials.gov 标识符：NCT04842240）招募了在利兹乳腺科接受即刻 IBR 手术的患者（2019 年 9 月至 2021 年 9 月）。数据收集包括患者特征和术后并发症。使用BREAST-Q问卷收集基线、术后2周、3个月和12个月的患者报告结果：78名患者接受了IBR手术（46名患者为胸骨前手术，占59%；32名患者为胸骨下手术，占41%）。并发症发生率相似（胸骨前 15.2% 对胸骨下 9.4%；P = 0.44）。总体植入物丢失率为 3.8%（胸骨前 6.5% 对胸骨下 0%；p = 0.13）。胸骨前和胸骨下 IBR 在 3 个月时的乳房-Q 评分中位数分别为：乳房满意度（58 分 vs. 48 分；p = 0.01）、社会心理健康（60 分 vs. 57 分；p = 0.9）、身体健康（68 分 vs. 76 分；p = 0.53）和动画 Q 评分（73 分 vs. 76 分；p = 0.45）。12 个月时的乳房-Q 评分分别为：乳房满意度（58 vs. 53；p = 0.3）、社会心理健康（59 vs. 60；p = 0.9）、身体健康（68 vs. 78；p = 0.18）和动画 Q 评分（69 vs. 73；p = 0.4）：这项研究表明，口腔前和口腔下 IBR 的临床效果和患者感知效果相当。研究结果可用于帮助患者就两种手术方案做出明智的决策。
Three and twelve-month analysis of the PROM-Q study: comparison of patient-reported outcome measures using the BREAST-Q questionnaire in pre- vs. sub-pectoral implant-based immediate breast reconstruction.
Purpose: Implant-based breast reconstruction (IBR) is being increasingly performed with implant placed above the pectoral muscle (pre-pectoral), instead of below the pectoral muscle (sub-pectoral). Currently, there is a lack of comparative data on clinical and patient-perceived outcomes between pre- vs. sub-pectoral IBR. We investigated whether this difference in surgical approach influenced clinical or patient-perceived outcomes.
Methods: This prospective non-randomised longitudinal cohort study (ClinicalTrials.gov identifier: NCT04842240) recruited patients undergoing immediate IBR at the Leeds Breast Unit (Sep 2019-Sep 2021). Data collection included patient characteristics and post-operative complications. Patient-Reported Outcome Measures were collected using the BREAST-Q questionnaire at baseline, 2 weeks, 3- and 12-months post-surgery.
Results: Seventy-eight patients underwent IBR (46 patients pre-pectoral; 59% vs. 32 patients sub-pectoral; 41%). Similar complication rates were observed (15.2% pre-pectoral vs. 9.4% sub-pectoral; p = 0.44). Overall implant loss rate was 3.8% (6.5% pre-pectoral vs. 0% sub-pectoral; p = 0.13). Respective median Breast-Q scores for pre- and sub-pectoral IBR at 3 months were: breast satisfaction (58 vs. 48; p = 0.01), psychosocial well-being (60 vs. 57; p = 0.9), physical well-being (68 vs. 76; p = 0.53), and Animation Q scores (73 vs. 76; p = 0.45). Respective Breast-Q scores at 12 months were: breast satisfaction (58 vs. 53; p = 0.3), psychosocial well-being (59 vs. 60; p = 0.9), physical well-being (68 vs. 78; p = 0.18), and Animation Q scores (69 vs. 73; p = 0.4).
Conclusions: This study demonstrates equivalent clinical and patient-perceived outcomes between pre- and sub-pectoral IBR. The study findings can be utilised to aid informed decision making regarding either surgical option.
期刊介绍：
Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
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