听觉脑干反应测听法在人类阿尔茨海默病牛磺酸病小鼠模型中的应用

IF 1.2 Q3 ACOUSTICS
Kali Burke, Laurel A Screven, Sergio Vicencio-Jimenez, Amanda M Lauer
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种渐进性神经退行性疾病,其听力敏感性的变化先于认知能力的下降。尽管众所周知痴呆症与听力损失之间存在联系,但很少有阿兹海默症模型小鼠品系具有听力特征。我们利用听性脑干反应(ABR)对患有 P301S tauopathy 的幼年(3-4 个月)和老龄(9-10 个月)小鼠(PS19 小鼠)进行了听力损失筛查。与野生型小鼠相比,老龄 PS19 小鼠没有表现出加速性听力损失,但在中心产生的 ABR 波形成分中表现出潜伏期差异。这些结果表明,tauopathy会导致轻微的中枢听觉功能障碍,而不会出现明显的听力损失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Auditory brainstem response audiometry in tauopathy mouse model of human Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which changes in hearing sensitivity precede cognitive decline. Despite a well-known link between dementia and hearing loss, few AD model mouse lines have hearing characterized. We screened for hearing loss using auditory brainstem responses (ABR) in young (3-4 months) and aging (9-10 months) mice with a P301S tauopathy (PS19 mice). Compared to wild types, aging PS19 mice did not show accelerated hearing loss but did show latency differences in centrally generated ABR waveform components. These results suggest that tauopathy causes mild central auditory dysfunction in the absence of overt hearing loss.

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