Qing-yue Ma , Xiao-yan Xu , Yuan-zhang Zhu, Ning-ning Yao, Yi-chong Liu, Xiao-di Gao, Qian Zhang, Wen-juan Luo
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引用次数: 0
摘要
脉络膜黑色素瘤（CM）是一种高度转移性眼部肿瘤，在缺氧诱导的血管生成作用下表现出血管生成模拟（VM）。本研究探讨了抗疟疾药物青蒿琥酯（ART）通过调节 HIF-1α/VEGF/PDGF 通路对 CM VM 的抑制作用。免疫组化（IHC）证实了血管内皮生长因子（VEGF）和表皮生长因子（PDGF）表达升高的 CM 中的血管瘤。缺氧促进了 CM 的增殖，上调了 HIF-1α、VEGF 和 PDGF。VEGF 和 PDGF 增强了 CM 的迁移、侵袭和 VM，其中 HIF-1α 起着关键作用。ART通过抑制HIF-1α/VEGF/PDGF通路缓解了VM的形成，突出了其作为CM抗肿瘤药物的潜力。
Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway
Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM.
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