Giusyda Tarantino, Rebecca Nicolai, Angela Aquilani, Andrea Tomasini, Antonella Celano, Aurora Pucacco, Silvia Magni-Manzoni, Fabrizio De Benedetti, Emiliano Marasco
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The Italian version of the MISS was validated in 125 patients with juvenile idiopathic arthritis (JIA) followed at the Rheumatology Unit of Bambino Gesù Children Hospital. We assessed the construct validity and calculated the internal consistency of the Italian MISS. We performed ROC analysis to assess the overall performance of the Italian MISS.</p><p><strong>Results: </strong>We translated and adapted the MISS to the Italian language. The Italian MISS showed a very good internal consistency as shown by a Cronbach α of 0.87 (95% CI, 0.84-0.90) and a composite reliability of 0.89 (95% CI, 0.83-0.91).The Cohen's κ was 0.81 (95% CI, 0.71-0.91), suggesting a very good construct validity. The ROC analysis showed an area under the curve (AUC) of 0.97 (95% CI, 0.93-0.99). A threshold of 6 to define intolerant patients, showed a sensitivity of 98.3% and specificity of 81.2%.</p><p><strong>Conclusions: </strong>We developed the Italian version of the MISS and showed its validity and reliability to identify patients intolerant to MTX in clinical practice and in a research setting.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Translation and validation in Italian of the methotrexate intolerance severity score for children and adults with arthritis.\",\"authors\":\"Giusyda Tarantino, Rebecca Nicolai, Angela Aquilani, Andrea Tomasini, Antonella Celano, Aurora Pucacco, Silvia Magni-Manzoni, Fabrizio De Benedetti, Emiliano Marasco\",\"doi\":\"10.55563/clinexprheumatol/656se0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Methotrexate (MTX) is the most used drug to treat children and adults with arthritis and its use is burdened by adverse effects. The MTX intolerance severity score (MISS) was developed in English to identify patients who are intolerant to MTX. The aim of this study was to translate and validate the MISS in Italian.</p><p><strong>Methods: </strong>The Italian version of the MISS was developed following the \\\"guidelines for process of cross-cultural adaptation of self-reported measures\\\". The Italian version of the MISS was validated in 125 patients with juvenile idiopathic arthritis (JIA) followed at the Rheumatology Unit of Bambino Gesù Children Hospital. We assessed the construct validity and calculated the internal consistency of the Italian MISS. We performed ROC analysis to assess the overall performance of the Italian MISS.</p><p><strong>Results: </strong>We translated and adapted the MISS to the Italian language. 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引用次数: 0
摘要
目的:甲氨蝶呤(MTX)是治疗儿童和成人关节炎最常用的药物,但其不良反应也给使用带来了负担。MTX不耐受严重程度评分(MISS)是用英语开发的,用于识别对MTX不耐受的患者。本研究旨在翻译并验证意大利语版的 MISS:方法:意大利语版的 MISS 是根据 "自我报告测量的跨文化适应过程指南 "开发的。在班比诺-格苏(Bambino Gesù)儿童医院风湿科的 125 名幼年特发性关节炎(JIA)患者中对意大利语版 MISS 进行了验证。我们评估了意大利 MISS 的结构效度,并计算了其内部一致性。我们进行了ROC分析,以评估意大利语MISS的整体表现:我们将 MISS 翻译并调整为意大利语。意大利语 MISS 的 Cronbach α 为 0.87(95% CI,0.84-0.90),综合信度为 0.89(95% CI,0.83-0.91),显示出非常好的内部一致性。ROC分析显示曲线下面积(AUC)为0.97(95% CI,0.93-0.99)。以 6 为阈值定义不耐受患者的灵敏度为 98.3%,特异度为 81.2%:我们开发了意大利版 MISS,并证明了它在临床实践和研究环境中识别 MTX 不耐受患者的有效性和可靠性。
Translation and validation in Italian of the methotrexate intolerance severity score for children and adults with arthritis.
Objectives: Methotrexate (MTX) is the most used drug to treat children and adults with arthritis and its use is burdened by adverse effects. The MTX intolerance severity score (MISS) was developed in English to identify patients who are intolerant to MTX. The aim of this study was to translate and validate the MISS in Italian.
Methods: The Italian version of the MISS was developed following the "guidelines for process of cross-cultural adaptation of self-reported measures". The Italian version of the MISS was validated in 125 patients with juvenile idiopathic arthritis (JIA) followed at the Rheumatology Unit of Bambino Gesù Children Hospital. We assessed the construct validity and calculated the internal consistency of the Italian MISS. We performed ROC analysis to assess the overall performance of the Italian MISS.
Results: We translated and adapted the MISS to the Italian language. The Italian MISS showed a very good internal consistency as shown by a Cronbach α of 0.87 (95% CI, 0.84-0.90) and a composite reliability of 0.89 (95% CI, 0.83-0.91).The Cohen's κ was 0.81 (95% CI, 0.71-0.91), suggesting a very good construct validity. The ROC analysis showed an area under the curve (AUC) of 0.97 (95% CI, 0.93-0.99). A threshold of 6 to define intolerant patients, showed a sensitivity of 98.3% and specificity of 81.2%.
Conclusions: We developed the Italian version of the MISS and showed its validity and reliability to identify patients intolerant to MTX in clinical practice and in a research setting.
期刊介绍:
Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.