基于电化学阻抗能谱（EIS）的无线生物传感器模型的制作和特性分析，用于检测血浆中的 HER2 作为治疗药物

IF 1.6 4区工程技术 Q3 INSTRUMENTS & INSTRUMENTATION

Sensor Review Pub Date : 2024-07-05 DOI:10.1108/sr-05-2024-0425

Majid Monajjemi, Fatemeh Mollaamin

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引用次数: 0

摘要

因此，我们的目标是评估监测血浆中人表皮生长因子受体 2（HER2）水平的早期变化（使用 EIS）是否有助于乳腺癌的治疗？人表皮生长因子受体 2（HER2）过表达是癌症早期治疗选择的重要生物标志物。血癌血浆中 HER2 基因的联合检测为其他组织转移的预后提供了重要的参考指标。为此，作者制作并表征了一种基于电化学阻抗光谱（EIS）的无线生物传感器模型，用于检测血浆中的 HER2 作为治疗药物。虽然这类传感器具有合适的灵敏度和快速反应能力，但在各种设备中，连接线可能会限制传感能力。研究结果设计了用于检测 HER2、HER3 和 HER-4 的片上生物传感器结构，该结构由六个单元的丝网印刷电极（SPE）组成，SPE 由金/银、银/银或碳电极组成的电化学装置构成。结果表明，该生物传感器对低浓度血浆中的 HER2 具有完全的选择性，而且通过标准添加法检测 HER2 具有线性曲线图，因此使用这种生物传感器可以检测血浆中的 HER2。

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Fabrication and characterization of model wireless biosensor-based electrochemical impedance spectroscopy (EIS) for detecting HER2 in plasma as therapeutics

Purpose

Early prediction of any type of cancer is important for the treatment of this type of disease, therefore, our target to evaluate whether monitoring early changes in plasma human epidermal growth factor receptor 2 (HER2) levels (using EIS), could help in the treatment of breast cancer or not? Human epidermal growth factor receptor 2 (HER2) overexpression is an important biomarker for treatment selection in earlier stages of cancers. The combined detection of the HER2 gene in plasma for blood cancer provides an important reference index for the prognosis of metastasis to other tissues. For this purpose, the authors fabricated and characterized a model wireless biosensor-based electrochemical impedance spectroscopy (EIS) for detecting HER2 plasma as therapeutics.

Design/methodology/approach

Most sensors generally are fabricated based on a connection between component of the sensors and the external circuits through wires. Although these types of sensors provide suitable sensitivities and also quick responses, the connection wires can be limited to the sensing ability in various devices approximately. Therefore, the authors designed a wireless sensor, which can provide the advantages of in vivo sensing and also long-distance sensing, quickly.

Findings

The biosensor structure was designed for detection of HER2, HER3 and HER-4 from lab-on-chip approach with six units of screen-printed electrode (SPE), which is built of an electrochemical device of gold/silver, silver/silver or carbon electrodes. The results exhibited that the biosensor is completely selective at low concentrations of the plasma and HER2 detection via the standard addition approach has a linearity plot, therefore, by using this type of biosensors HER2 in plasma can be detected.

Originality/value

This is then followed by detecting HER2 in real plasma using standard way which proved to have great linearity (R² = 0.991) proving that this technique can be used to detect HER2 solution in real patients.

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来源期刊

Sensor Review 工程技术-仪器仪表

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

3.7 months

期刊介绍： Sensor Review publishes peer reviewed state-of-the-art articles and specially commissioned technology reviews. Each issue of this multidisciplinary journal includes high quality original content covering all aspects of sensors and their applications, and reflecting the most interesting and strategically important research and development activities from around the world. Because of this, readers can stay at the very forefront of high technology sensor developments. Emphasis is placed on detailed independent regular and review articles identifying the full range of sensors currently available for specific applications, as well as highlighting those areas of technology showing great potential for the future. The journal encourages authors to consider the practical and social implications of their articles. All articles undergo a rigorous double-blind peer review process which involves an initial assessment of suitability of an article for the journal followed by sending it to, at least two reviewers in the field if deemed suitable. Sensor Review’s coverage includes, but is not restricted to: Mechanical sensors – position, displacement, proximity, velocity, acceleration, vibration, force, torque, pressure, and flow sensors Electric and magnetic sensors – resistance, inductive, capacitive, piezoelectric, eddy-current, electromagnetic, photoelectric, and thermoelectric sensors Temperature sensors, infrared sensors, humidity sensors Optical, electro-optical and fibre-optic sensors and systems, photonic sensors Biosensors, wearable and implantable sensors and systems, immunosensors Gas and chemical sensors and systems, polymer sensors Acoustic and ultrasonic sensors Haptic sensors and devices Smart and intelligent sensors and systems Nanosensors, NEMS, MEMS, and BioMEMS Quantum sensors Sensor systems: sensor data fusion, signals, processing and interfacing, signal conditioning.