在一项使用核磁共振成像技术的多站点纵向研究中,内脏脂肪组织测量技术的比较与精度。

IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Samuel Barnes , Erica Kinne , Shilpy Chowdhury , Spencer Loong , Jeremy Moretz , Joan Sabate
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引用次数: 0

摘要

背景:使用磁共振成像(MRI)测量内脏脂肪组织(VAT)被认为是准确和安全的。在横断面观察研究中,单切片测量与容积测量的性能相似,但在纵向研究中可能表现不佳。本研究在一项前瞻性纵向研究中比较了单切片和容积式 VAT 测量的性能。研究还评估了不同地点和不同时间的结果一致性:在美国的四个临床中心开展了一项随机、对照、平行臂、非盲研究,共招募了 935 名健康参与者,对他们进行了两次核磁共振成像扫描,每次间隔约六个月。采用三维狄克逊核磁共振成像序列对腹部进行成像,并对腹部、缩小覆盖体积(11 片和 25 片)以及定位在解剖标记处的单片的内脏脂肪体积进行量化。在所有成像部位对一个移动模型进行了两次扫描:结果:单片 VAT 测量与全腹容积测量的相关性,横断面观察测量为 0.78 至 0.93,纵向变化为 0.30 至 0.55。缩小覆盖范围的容积测量结果优于单切片测量结果,但随着切片数量的增加,测量精度仍有所提高,11 片切片的横断面观察相关性和纵向相关性分别为 0.94 和 0.66,25 片切片的横断面观察相关性和纵向相关性分别为 0.94 和 0.70。旅行模型在不同部位或不同时间没有观察到明显差异,体积测量的标准偏差为14.1毫升,占测量体积的2.6%:结论:单片 VAT 测量与腹部 VAT 容积纵向变化的相关性明显低于横断面观察测量,可能不适合纵向研究。来自多个部位、不同扫描仪和不同时间的数据并未显示出显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison and precision of visceral adipose tissue measurement techniques in a multisite longitudinal study using MRI

Background

Measurement of visceral adipose tissue (VAT) using magnetic resonance imaging (MRI) is considered accurate and safe. Single slice measurements perform similar to volumetric measurements for cross-sectional observation studies but may not perform as well for longitudinal studies. This study compared the performance of single slice to volumetric VAT measurements in a prospective longitudinal study. Consistency of results across sites and over time was also evaluated.

Methods

A total of 935 healthy participants were recruited and scanned with MRI twice, approximately six months apart as part of a randomized, controlled, parallel arm, unblinded study conducted at four clinical centers in the United States. A 3D Dixon MRI sequence was used to image the abdomen, and visceral fat volumes were quantified for the abdomen, reduced coverage volumes (11 and 25 slices), and at single slices positioned at anatomical landmarks. A traveling phantom was scanned twice at all imaging sites.

Results

The correlation of single slice VAT measurement to full abdomen volumetric measurements ranged from 0.78 to 0.93 for cross-sectional observation measurements and 0.30 to 0.55 for longitudinal change. Reduced coverage volumetric measurement outperformed single slice measurements but still showed improved precision with more slices with cross-sectional observation and longitudinal correlations of 0.94 and 0.66 for 11 slices and 0.94 and 0.70 for 25 slices, respectively. No significant differences were observed across sites or over time with the traveling phantom and the volume measurements had a standard deviation of 14.1 mL, 2.6% of the measured volume.

Conclusion

Single slice VAT measurements had significantly lower correlation with abdomen VAT volume for longitudinal change than for cross-sectional observation measurements and may not be suitable for longitudinal studies. Data from multiple sites, different scanners, and over time did not show significant differences.

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来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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