Silai Yu MD , Shanshan Jiang PhD , Yue Zhou MD , Zhengfei Zhu PhD , Xi Yang PhD
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We screened all the related articles and summarized their main discoveries and important results.</p></div><div><h3>Results</h3><p>This article reviewed the effects of tumor derived exosomes and immune cell-derived exosomes on TME and tumor progression after radiotherapy, suggesting the dual effects of exosomes which may refer to clinical practice. Moreover, we retrospected the clinical applications based on tumor derived exosomes, including liquid biopsy, radio-resistance and drug delivery, and discussed the challenges and prospects.</p></div><div><h3>Conclusions</h3><p>Exosomes are important in cancer treatment, especially with radiation therapy. Learning more about them could lead to better treatments. However, there are still challenges to overcome. 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引用次数: 0
摘要
目的外泌体已被证明在癌症进展的大多数（如果不是全部）步骤中发挥作用。我们对外泌体在肿瘤细胞和免疫细胞之间的双向交流还缺乏全面的了解。本文旨在探讨外泌体如何影响癌症的生长以及放疗对它们的影响。方法和材料我们在PubMed和Web of Science上搜索了辐射对肿瘤免疫微环境中肿瘤衍生外泌体和免疫细胞衍生外泌体的影响。结果本文综述了放疗后肿瘤衍生外泌体和免疫细胞衍生外泌体对肿瘤免疫微环境和肿瘤进展的影响，提出了外泌体的双重作用，可为临床实践提供参考。此外，我们还回顾了基于肿瘤衍生外泌体的临床应用，包括液体活检、放射抗性和药物递送，并讨论了面临的挑战和前景。了解更多关于外泌体的信息可带来更好的治疗方法。然而，仍有一些挑战需要克服。综述指出了在这一领域开展更多研究的必要性。
Impact of Radiation on Exosomes in Regulating Tumor Immune Microenvironment
Purpose
Exosomes have been shown to play a role in most, if not all, steps of cancer progression. We still lack a comprehensive understanding of the bidirectional communication of exosomes between tumor cells and immune cells. This article aims to explore how exosomes can influence cancer growth and how they are affected by radiation therapy.
Methods and Materials
We searched on PubMed and Web of Science on the impact of radiation on tumor derived exosomes and immune cell derived exosomes in tumor immune microenvironment. We screened all the related articles and summarized their main discoveries and important results.
Results
This article reviewed the effects of tumor derived exosomes and immune cell-derived exosomes on TME and tumor progression after radiotherapy, suggesting the dual effects of exosomes which may refer to clinical practice. Moreover, we retrospected the clinical applications based on tumor derived exosomes, including liquid biopsy, radio-resistance and drug delivery, and discussed the challenges and prospects.
Conclusions
Exosomes are important in cancer treatment, especially with radiation therapy. Learning more about them could lead to better treatments. However, there are still challenges to overcome. The review points out the need for more research in this area.
期刊介绍：
The purpose of Advances is to provide information for clinicians who use radiation therapy by publishing: Clinical trial reports and reanalyses. Basic science original reports. Manuscripts examining health services research, comparative and cost effectiveness research, and systematic reviews. Case reports documenting unusual problems and solutions. High quality multi and single institutional series, as well as other novel retrospective hypothesis generating series. Timely critical reviews on important topics in radiation oncology, such as side effects. Articles reporting the natural history of disease and patterns of failure, particularly as they relate to treatment volume delineation. Articles on safety and quality in radiation therapy. Essays on clinical experience. Articles on practice transformation in radiation oncology, in particular: Aspects of health policy that may impact the future practice of radiation oncology. How information technology, such as data analytics and systems innovations, will change radiation oncology practice. Articles on imaging as they relate to radiation therapy treatment.
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