比利时蓝犬对疥癣病易感性的遗传和基因组分析。

IF 3.6 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Roel Meyermans, Steven Janssens, Annelies Coussé, Susanne Tinel, Wim Gorssen, Fabrice Lepot, Xavier Hubin, Patrick Mayeres, Wim Veulemans, Nathalie De Wilde, Tom Druet, Michel Georges, Carole Charlier, Edwin Claerebout, Nadine Buys
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引用次数: 0

摘要

背景:由猫鼬螨引起的疥癣病正在影响比利时蓝牛的福利和生产潜力。比利时蓝牛以肌肉发达、饲料转化率低和牛肉品质高而著称,极易感染这种疾病:在这项研究中,我们对来自商业化肉牛养殖场 100 多个不同群体的 1975 头比利时蓝牛进行了表型分析,以确定它们对疥癣病的易感性。在这些管理组中观察到了巨大的个体差异,病变程度差异高达 ± 15%。动物模型显示,皮损范围和严重皮损范围的估计遗传率较低(分别为 0.07 和 0.09),螨虫数量的估计遗传率为 0.12。一项关于疥癣易感性的全基因组关联研究发现了 BTA6、BTA11、BTA15 和 BTA24 上的信号。在这些区域,发现了候选基因 GBA3、RAG2 和 TRAF6:尽管由于筛查的时间、病变的持续演变和不同的管理条件等原因,在对牛疥癣进行表型分析时遇到了挑战,但我们还是成功地对比利时蓝牛的牛疥癣遗传易感性进行了研究。我们的研究结果清楚地表明,疥癣病是由多基因控制的,因此应该对潜在的候选基因进行更深入的研究。这是首次为这种复杂疾病提供候选基因的研究。这些结果对于比利时蓝牛的育种已经很有价值,但是还需要进一步的研究来揭示这种疾病的结构并确定致病突变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic and genomic analysis of Belgian Blue's susceptibility for psoroptic mange.

Background: Psoroptic mange, caused by Psoroptes ovis mites, is affecting Belgian Blue cattle's welfare and production potential. The Belgian Blue cattle-known for its high degree of muscling, low feed conversion ratio and high beef quality-is highly susceptible for this disease.

Results: In this study, we phenotyped 1975 Belgian Blue cattle from more than 100 different groups on commercial beef farms for their psoroptic mange susceptibility. Substantial individual differences were observed within these management groups, with lesion extent differences up to ± 15%. Animal models showed that estimated heritabilities were low for lesion extent and severe lesion extent (0.07 and 0.09, respectively) and 0.12 for the number of mites. A genome wide association study for mange susceptibility revealed signals on BTA6, BTA11, BTA15 and BTA24. In these regions, candidate genes GBA3, RAG2, and TRAF6 were identified.

Conclusions: Despite the challenges in phenotyping for psoroptic mange due to the timing of screening, the continuous evolution of lesions and different management conditions, we successfully conducted a study on the genetic susceptibility to psoroptic mange in Belgian Blue cattle. Our results clearly indicate that psoroptic mange is under polygenic control and the underlying candidate genes should be studied more thoroughly. This is the first study providing candidate genes for this complex disease. These results are already valuable for Belgian Blue breeding, however, further research is needed to unravel the architecture of this disease and to identify causal mutations.

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来源期刊
Genetics Selection Evolution
Genetics Selection Evolution 生物-奶制品与动物科学
CiteScore
6.50
自引率
9.80%
发文量
74
审稿时长
1 months
期刊介绍: Genetics Selection Evolution invites basic, applied and methodological content that will aid the current understanding and the utilization of genetic variability in domestic animal species. Although the focus is on domestic animal species, research on other species is invited if it contributes to the understanding of the use of genetic variability in domestic animals. Genetics Selection Evolution publishes results from all levels of study, from the gene to the quantitative trait, from the individual to the population, the breed or the species. Contributions concerning both the biological approach, from molecular genetics to quantitative genetics, as well as the mathematical approach, from population genetics to statistics, are welcome. Specific areas of interest include but are not limited to: gene and QTL identification, mapping and characterization, analysis of new phenotypes, high-throughput SNP data analysis, functional genomics, cytogenetics, genetic diversity of populations and breeds, genetic evaluation, applied and experimental selection, genomic selection, selection efficiency, and statistical methodology for the genetic analysis of phenotypes with quantitative and mixed inheritance.
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