碱基切除修复基因多态性与雌激素-DNA 加合物在东亚妇女乳腺癌风险中的相互作用。

IF 3 3区 医学 Q2 ONCOLOGY
Breast Cancer Research and Treatment Pub Date : 2024-11-01 Epub Date: 2024-07-05 DOI:10.1007/s10549-024-07418-3
Hsing-Wu Chen, Wen-Hung Kuo, Yen-Shen Lu, I-Chun Chen, Fu-Chang Hu, Ming-Yang Wang, Muhammad Zahid, Eleanor G Rogan, Ann-Lii Cheng, Ching-Hung Lin
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引用次数: 0

摘要

目的:在东亚,乳腺癌的发病率迅速上升,尤其是绝经前妇女。雌激素-DNA 加合物比值升高与乳腺癌风险升高有关。本研究探讨了碱基切除修复(BER)基因多态性与雌激素-DNA加合物之间的相互作用对乳腺癌风险的影响:我们进行了一项病例对照研究,研究对象包括健康志愿者和良性乳腺疾病患者(对照组,n = 176)以及浸润癌或原位癌患者(病例组,n = 177)。对 BER 相关基因(包括 SMUG1、OGG1、ERCC5 和 APEX1)进行了基因分型。采用逻辑回归模型,结合基因多态性、雌激素-DNA加合物比值和临床变量之间的相互作用,确定乳腺癌的风险因素:单变量分析表明,乳腺癌风险与APEX1 rs1130409 T > G(P = 0.057)和APEX1 rs1760944 T > G(P = 0.065)之间存在边际关联。多变量回归分析显示,APEX1_rs1130409(GT/GG 与 TT)与雌激素-DNA 加合物比值的自然对数值(估计 OR 1.164,P = 0.023)以及绝经前状态与雌激素-DNA 加合物比值 > 2.93(估计 OR 2.433,P = 0.001)均与乳腺癌风险增加有显著关联:结论:APEX1_rs1130409(GT/GG 与 TT)多态性与 BER 活性降低有关,再加上雌激素-DNA 加合物比率升高,会增加东亚女性罹患乳腺癌的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women.

Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women.

Purpose: In East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of estrogen-DNA adducts was linked to a higher risk of breast cancer. The present study explored the influence of the interaction between base excision repair (BER) gene polymorphisms and estrogen-DNA adducts on breast cancer risk.

Methods: We conducted a case-control study comprising healthy volunteers and individuals with benign breast disease (control arm, n = 176) and patients with invasive carcinoma or carcinoma in situ (case arm, n = 177). Genotyping for BER-related genes, including SMUG1, OGG1, ERCC5, and APEX1, was performed. A logistic regression model, incorporating interactions between gene polymorphisms, estrogen-DNA adduct ratio, and clinical variables, was used to identify the risk factors for breast cancer.

Results: Univariate analysis indicated marginal associations between breast cancer risk and APEX1 rs1130409 T > G (P = 0.057) and APEX1 rs1760944 T > G (P = 0.065). Multivariate regression analysis revealed significant associations with increased breast cancer risk for APEX1_rs1130409 (GT/GG versus TT) combined with a natural logarithmic value of the estrogen-DNA adduct ratio (estimated OR 1.164, P = 0.023) and premenopausal status with an estrogen-DNA adduct ratio > 2.93 (estimated OR 2.433, P = 0.001).

Conclusion: APEX1_rs1130409 (GT/GG versus TT) polymorphisms, which are related to decreased BER activity, combined with an increased ratio of estrogen-DNA adducts, increase the risk of breast cancer in East Asian women.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
342
审稿时长
1 months
期刊介绍: Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
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