通过 Ia 型糖原贮积症患者的血清去γ-羧基凝血酶原筛查和监测肝细胞癌

IF 1.8 Q2 Biochemistry, Genetics and Molecular Biology

JIMD reports Pub Date : 2024-05-29 DOI:10.1002/jmd2.12414

A. B. Schreuder, R. J. Overduin, N. C. Peltenburg, L. de Boer, F. A. J. A. Bodewes, T. G. J. Derks

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引用次数: 0

摘要

Ia 型糖原贮积病（GSDIa）患者的甲胎蛋白和癌胚抗原水平通常保持正常，但目前还没有针对肝细胞癌（HCC）的敏感肿瘤标志物。我们描述了患有 HCC 的 GSDIa 患者体内 HCC 肿瘤标志物去γ-羧基凝血酶原（DCP）水平升高的情况。在一个病例中，肝移植后 DCP 水平恢复正常。我们建议将 DCP 作为筛查 HCC 肿瘤标志物纳入 GSDIa 患者的监测中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia

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Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia

No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.

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来源期刊

JIMD reports Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

12 weeks