[异基因造血干细胞移植治疗 KMT2A 重排急性白血病的进展]。

Q3 Medicine

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi Pub Date : 2024-05-14 DOI:10.3760/cma.j.cn121090-20231026-00230

J Liu, X J Huang

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引用次数: 0

摘要

KMT2A（赖氨酸甲基转移酶2A）重排急性白血病是一类具有独特生物学特征的白血病，预后中等或较差。近年来，异基因造血干细胞移植（allo-HSCT）越来越多地用于 KMT2A 重排急性白血病患者。通过回顾KMT2A重排急性白血病异基因造血干细胞移植的临床研究，评估了异基因造血干细胞移植在儿童和成人KMT2A重排急性髓性白血病和急性淋巴细胞白血病患者中的疗效，总结了影响异基因造血干细胞移植预后的因素，并探讨了可改善异基因造血干细胞移植预后的方法。

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[Progress of allogeneic hematopoietic stem cell transplantation in KMT2A-rearranged acute leukemia].

KMT2A (lysine methyltransferase 2A) -rearranged acute leukemia is a class of leukemia with unique biological characteristics with moderate or poor prognosis. In recent years, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been increasingly indicated for patients with KMT2A-rearranged acute leukemia. By reviewing the clinical studies of allo-HSCT in KMT2A-rearranged acute leukemia, the efficacy of allo-HSCT in children and adults with KMT2A-rearranged acute myeloid leukemia and acute lymphoblastic leukemia was assessed, the factors affecting the prognosis of allo-HSCT were summarized, and the methods that may improve the outcomes of allo-HSCT were explored.

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来源期刊

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi Medicine-Medicine (all)

CiteScore

0.80

自引率

0.00%

发文量

100