MASLD 中的肠道微生物代谢物:线粒体功能障碍在发病和治疗中的影响。

IF 5.6 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Hepatology Communications Pub Date : 2024-07-05 eCollection Date: 2024-07-01 DOI:10.1097/HC9.0000000000000484
Ruhan Zhang, Zhaobo Yan, Huan Zhong, Rong Luo, Weiai Liu, Shulin Xiong, Qianyan Liu, Mi Liu
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引用次数: 0

摘要

随着发病率的不断上升,代谢功能障碍相关性脂肪性肝病(MASLD)已成为全球主要的健康问题。众所周知,代谢性脂肪肝是一种多因素疾病。线粒体功能障碍和肠道细菌的改变是导致代谢性脂肪肝的两个重要因素。最近的研究强调了微生物群与线粒体之间的交叉对话,线粒体被认为是肠道微生物群调节宿主生理状态的关键目标。线粒体功能障碍在 MASLD 中起着至关重要的作用,并与多种病理变化有关,包括肝细胞脂肪变性、氧化应激、炎症和纤维化。代谢物是影响肠道外器官的肠道微生物群的重要介质。此外,调节肠道细菌的组成可能是治疗 MASLD 的一种有前途的策略。本研究综述了几种常见代谢物在 MASLD 中的潜在作用,强调了它们对线粒体功能的影响。最后,我们讨论了目前治疗 MASLD 的方法,包括益生菌、益生元、抗生素和粪便微生物群移植。这些方法的重点是恢复肠道微生物群以促进宿主健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut microbial metabolites in MASLD: Implications of mitochondrial dysfunction in the pathogenesis and treatment.

With an increasing prevalence, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major global health problem. MASLD is well-known as a multifactorial disease. Mitochondrial dysfunction and alterations in the gut bacteria are 2 vital events in MASLD. Recent studies have highlighted the cross-talk between microbiota and mitochondria, and mitochondria are recognized as pivotal targets of the gut microbiota to modulate the host's physiological state. Mitochondrial dysfunction plays a vital role in MASLD and is associated with multiple pathological changes, including hepatocyte steatosis, oxidative stress, inflammation, and fibrosis. Metabolites are crucial mediators of the gut microbiota that influence extraintestinal organs. Additionally, regulation of the composition of gut bacteria may serve as a promising therapeutic strategy for MASLD. This study reviewed the potential roles of several common metabolites in MASLD, emphasizing their impact on mitochondrial function. Finally, we discuss the current treatments for MASLD, including probiotics, prebiotics, antibiotics, and fecal microbiota transplantation. These methods concentrate on restoring the gut microbiota to promote host health.

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来源期刊
Hepatology Communications
Hepatology Communications GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
8.00
自引率
2.00%
发文量
248
审稿时长
8 weeks
期刊介绍: Hepatology Communications is a peer-reviewed, online-only, open access journal for fast dissemination of high quality basic, translational, and clinical research in hepatology. Hepatology Communications maintains high standard and rigorous peer review. Because of its open access nature, authors retain the copyright to their works, all articles are immediately available and free to read and share, and it is fully compliant with funder and institutional mandates. The journal is committed to fast publication and author satisfaction. ​
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