基于 Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines 的 4-羟基喹啉-2(1H)-酮的合成

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC

Letters in Organic Chemistry Pub Date : 2024-06-24 DOI:10.2174/0115701786302455240603070018

Xin-Yu Lin, Guo-Jun Chen, Su-Zhe Wu, Ke-Xuan Xu, Xiao-Tian Zhang, Qi Feng

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引用次数: 0

摘要

:4-羟基喹啉-2(1H)-酮具有多种生物活性，研究其合成方法具有重要意义。在四甲基胍和硝酸银存在下，4-羟基喹啉-2(1H)-酮在常压下由 2-乙炔基苯胺和二氧化碳高效合成。对银催化剂和反应溶剂等反应条件进行了优化，并初步研究了底物的适用性。该方法为 4-羟基喹啉-2(1H)-酮的合成以及二氧化碳的转化和利用提供了另一条途径。

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Synthesis of 4-hydroxyquinoline-2(1H)-ones Based on Ag(I)-catalyzed Carbon Dioxide Fixation on 2-alknylanilines

: 4-Hydroxyquinoline-2(1H)-ones exhibit multiple biological activities, and studying their synthetic methods is of great significance. In the presence of tetramethylguanidine and silver nitrate, 4-hydroxyquinoline-2(1H)-ones were efficiently synthesized from 2-ethynylanilines and carbon dioxide under atmospheric pressure. The reaction conditions, such as types of silver catalysts and reaction solvents, were optimized, and the applicability of the substrate was preliminarily investigated. This method provides an alternative pathway for the synthesis of 4-hydroxyquinoline-2(1H)-ones and the conversion and utilization of carbon dioxide.

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.