片上肾脏的进展：抗生素引起的肾损伤和未来发展方向

IF 5.5 3区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

BioChip Journal Pub Date : 2024-06-27 DOI:10.1007/s13206-024-00160-4

Min-Hyeok Kim, Yugyeong Lee, Gwang Myeong Seo, Sungsu Park

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引用次数: 0

摘要

本综述旨在批判性地评估片上肾脏（KOC）技术在研究抗生素诱发肾损伤方面的进步、挑战和未来前景。尽管取得了重大进展，但诸如有限的通量和需要更精确的生理复制等挑战依然存在。通过分析当前的文献和技术发展，本综述指出了关键问题，并概述了 KOC 研究的未来方向。通过对传感器集成、高通量筛选能力和自动化的探讨，本综述旨在应对这些挑战，推动 KOC 向更高效、更具预测性的药物测试方法发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advancements in Kidney-on-Chip: Antibiotic-Induced Kidney Injury and Future Directions

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Advancements in Kidney-on-Chip: Antibiotic-Induced Kidney Injury and Future Directions

This review paper aims to critically assess the advancements, challenges, and future prospects of kidney-on-chip (KOC) technology in studying antibiotic-induced kidney injury. Despite significant progress, challenges such as limited throughput and the need for more accurate physiological replication persist. By analyzing current literature and technological developments, this review identifies key issues and outlines future directions for KOC research. Through an exploration of sensor integration, high-throughput screening capabilities, and automation, this review seeks to address these challenges and propel KOC toward more efficient and predictive drug-testing methodologies.

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来源期刊

BioChip Journal 生物-生化研究方法

CiteScore

7.70

自引率

16.30%

发文量

审稿时长

6-12 weeks

期刊介绍： BioChip Journal publishes original research and reviews in all areas of the biochip technology in the following disciplines, including protein chip, DNA chip, cell chip, lab-on-a-chip, bio-MEMS, biosensor, micro/nano mechanics, microfluidics, high-throughput screening technology, medical science, genomics, proteomics, bioinformatics, medical diagnostics, environmental monitoring and micro/nanotechnology. The Journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.