Aminals 的合成和应用进展:分子多样性的支架

Synthesis Pub Date : 2024-06-10 DOI:10.1055/a-2317-6604
Rafael Rippel, Luísa M. Ferreira, Paula S. Branco
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引用次数: 0

摘要

氨基化合物的特点是一个中心碳连接两个氮原子,是现代化学中用途广泛的构筑基块。本综述通过探讨氨基化合物的合成和应用,填补了文献空白,重点关注药物发现和分子多样性。除药物化学外,氨基化合物还可作为生物活性化合物的关键成分和材料化学的多功能工具加以应用。这篇综述涵盖了基本特征、合成方法、稳定性和应用,并强调了除成熟的醛胺缩合之外的其他合成方法。这种包容性的探索为我们提供了对各种合成途径的深入了解,从而拓展了氨基化合物支架的多功能性。1 引言 2 氨基醛基 3 氨基醛合成 3.1 无金属方法 3.2 金属催化方法 3.3 光氧化方法 3.4 通过重排 3.5 通过脱羧偶联 4 氨基醛作为合成工具 5 含氨基醛天然产物的合成 6 氨基醛基材料 7 结论
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Progress on the Synthesis and Applications of Aminals: Scaffolds for Molecular Diversity

Aminals, characterized by a central carbon linking two nitrogen atoms, are versatile building blocks in modern chemistry. This review addresses a literature gap by exploring the synthesis and applications of aminals, with a focus on drug discovery and molecular diversity. Beyond medicinal chemistry, aminals find applications as key components in bioactive compounds and as versatile tools in materials chemistry. The review covers fundamental characteristics, synthetic methodologies, stability, and applications, emphasizing alternative synthetic methods to the well-established aldehyde–amine condensation. This inclusive exploration provides insights into diverse synthetic pathways that expand the versatility of the aminal scaffold.

1 Introduction

2 The Aminal Group

3 Aminal Synthesis

3.1 Metal-Free Approaches

3.2 Metal-Catalyzed Approaches

3.3 Photoredox Methodologies

3.4 Via Rearrangements

3.5 Via Decarboxylative Coupling

4 Aminals as Synthetic Tools

5 Synthesis of Aminal-Containing Natural Products

6 Aminal-Based Materials

7 Conclusions

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